| UniProt/SwissProt ID: | M3KL4_HUMAN |
| Description: | Mitogen-activated protein kinase kinase kinase MLK4 [Source:UniProtKB/Swiss-Prot;Acc:Q5TCX8] |
| Location: | chr1 q42.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S732 | TVLLAsVALGL | RegPhos | |
| Y724 | TESALyGCTVL | PhosphoSitePlus | |
| S114 | PPSRPsSPVHV | PhosphoSitePlus | |
| S618 | LSDGNsPWSTI | PhosphoSitePlus | |
| Y96 | IFPANyVAPCR | PhosphoSitePlus | |
| S806 | ILSTPsFSTKC | RegPhos | |
| S517 | RISLPsDFQHK | PhosphoSitePlus | |
| T604 | QMKDRtDCKER | PhosphoSitePlus | |
| S546 | SSSPPsSPTMM | HPRD | |
| S543 | NSSSSsPPSSP | PhosphoSitePlus; HPRD | |
| T719 | PQRKKtESALY | PhosphoSitePlus | |
| S528 | ITVQAsPNLDK | PhosphoSitePlus; HPRD | |
| T142 | QVYRAtWQGQE | Pkinase_Tyr | PhosphoSitePlus |
| T592 | KKKGCtWGPNS | PhosphoSitePlus | |
| S773 | SKSRRsASPPT | PhosphoSitePlus | |
| S621 | GNSPWsTILIK | PhosphoSitePlus | |
| S303 | RTTKMsTAGTY | HPK1(MAP4K1 | RegPhos |
| S455 | ALQQKsQEELL | DUF3552 | PhosphoSitePlus |
| S111 | PAPPPsRPSSP | PhosphoSitePlus | |
| S547 | SSPPSsPTMMP | RegPhos | |
| S542 | LNSSSsSPPSS | PhosphoSitePlus | |
| S597 | TWGPNsIQMKD | PhosphoSitePlus | |
| S514 | DGHRIsLPSDF | PhosphoSitePlus; HPRD | |
| S303 | RTTKMsTAGTY | autocatalysis | RegPhos |
| Y47 | LWAALyDYEAR | SH3_1 | PhosphoSitePlus |
| S614 | RIRPLsDGNSP | PhosphoSitePlus; HPRD; phosphoELM | |
| T622 | NSPWStILIKN | PhosphoSitePlus | |
| S105 | CRPAAsPAPPP | PhosphoSitePlus | |
| T299 | REWHRtTKMST | autocatalysis | RegPhos |
| Y669 | LPSQAyIDLPL | PhosphoSitePlus | |
| Dephosphorylation site |
| M3KL4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355583 | A392S | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000355583 | H386R | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000355583 | A922S | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000355583 | E741D | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000355583 | W310C | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000355583 | L729V | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| M3KL4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| M3KL4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | M3KL4_HUMAN | kinase -> substrate | RegPhos |
| M4K1_HUMAN | M3KL4_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| M3KL4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007257 | activation of JUN kinase activity | ISS | biological_process |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | ISS | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | ISS | molecular_function |
| GO:0006468 | protein phosphorylation | ISS | biological_process |