Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K4_HUMAN
Description:mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:6856]
Location:chr6 q26
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1271DSSGStRRSWEPhosphoSitePlus
T447YEGDDtEGELKAnophelinPhosphoSitePlus
S835AEFRLsAPVRDPhosphoSitePlus
S431VFEIPsPRPSKHPRD
S456LKELEsSTDESAnophelinPhosphoSitePlus
S461SSTDEsEEEQIAnophelinPhosphoSitePlus
S253GQENTsGFWLNPhosphoSitePlus
T458ELESStDESEEHPRD
S1068GDKYIsFARKWPhosphoSitePlus
S66CKSPEsDLEDFPhosphoSitePlus
S461SSTDEsEEEQIHPRD
Y1556NFQIMyKVGMGPkinasePhosphoSitePlus
Y81NTENLyGTSPPPhosphoSitePlus
Y582MWGSDyVQLSRPhosphoSitePlus
S457KELESsTDESEHPRD
Y140VEEYSyKQEKKPhosphoSitePlus
S72DLEDFsDETNTPhosphoSitePlus
S1270GDSSGsTRRSWPhosphoSitePlus
T447YEGDDtEGELKHPRD
Y138ENVEEySYKQEPhosphoSitePlus
S457KELESsTDESEAnophelinPhosphoSitePlus
Y1548RPWHEyEHNFQPkinasePhosphoSitePlus
Y442GNEPEyEGDDTAnophelinPhosphoSitePlus
S87GTSPPsTPRQMPhosphoSitePlus
Y1076RKWMNyVLTKCPhosphoSitePlus
S84NLYGTsPPSTPPhosphoSitePlus
S1252LSRHSsPTEERPhosphoSitePlus
S63DSACKsPESDLPhosphoSitePlus
T1494KNNAQtMPGEVPkinasePhosphoSitePlus
T458ELESStDESEEAnophelinPhosphoSitePlus
S1268PRGDSsGSTRRPhosphoSitePlus
S456LKELEsSTDESHPRD
S431VFEIPsPRPSKAnophelinPhosphoSitePlus
S173DSVGGsLPKKSPhosphoSitePlus
S499LERLEsEDDSLPhosphoSitePlus; HPRD

Dephosphorylation site
M3K4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000375986R558CCOSMICHepatocellular Carcinoma21822264
ENSP00000375986D483YTCGAOvarian Cancer21720365, 18772890
ENSP00000375986D575YDing2008Lung Cancer18948947
ENSP00000375986E1608KBIOMARTBreast Cancer21930507, 21930502
ENSP00000375986G505VDing2008Lung Cancer18948947
ENSP00000375986E1413QHPIOvarian Cancer17344846
ENSP00000375986P64SCOSMICGastric Cancer21097718
ENSP00000375986D565YDing2008Lung Cancer18948947

Differential expressed protein
M3K4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GA45G_HUMANM3K4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04912GnRH signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007254JNK cascadeTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0000186activation of MAPKK activityTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0060718chorionic trophoblast cell differentiationIEAbiological_process
GO:0019100male germ-line sex determinationIEAbiological_process
GO:0006950response to stressTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0001890placenta developmentIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function


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