Phosphorylation

Protein information

UniProt/SwissProt ID:	M3K4_HUMAN
Description:	mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:6856]
Location:	chr6 q26
Node attribute:	PPI(target)

Position	PhosphoPeptide	Catalytic kinase	Source
T1271	DSSGStRRSWE		PhosphoSitePlus
T447	YEGDDtEGELK	Anophelin	PhosphoSitePlus
S835	AEFRLsAPVRD		PhosphoSitePlus
S431	VFEIPsPRPSK		HPRD
S456	LKELEsSTDES	Anophelin	PhosphoSitePlus
S461	SSTDEsEEEQI	Anophelin	PhosphoSitePlus
S253	GQENTsGFWLN		PhosphoSitePlus
T458	ELESStDESEE		HPRD
S1068	GDKYIsFARKW		PhosphoSitePlus
S66	CKSPEsDLEDF		PhosphoSitePlus
S461	SSTDEsEEEQI		HPRD
Y1556	NFQIMyKVGMG	Pkinase	PhosphoSitePlus
Y81	NTENLyGTSPP		PhosphoSitePlus
Y582	MWGSDyVQLSR		PhosphoSitePlus
S457	KELESsTDESE		HPRD
Y140	VEEYSyKQEKK		PhosphoSitePlus
S72	DLEDFsDETNT		PhosphoSitePlus
S1270	GDSSGsTRRSW		PhosphoSitePlus
T447	YEGDDtEGELK		HPRD
Y138	ENVEEySYKQE		PhosphoSitePlus
S457	KELESsTDESE	Anophelin	PhosphoSitePlus
Y1548	RPWHEyEHNFQ	Pkinase	PhosphoSitePlus
Y442	GNEPEyEGDDT	Anophelin	PhosphoSitePlus
S87	GTSPPsTPRQM		PhosphoSitePlus
Y1076	RKWMNyVLTKC		PhosphoSitePlus
S84	NLYGTsPPSTP		PhosphoSitePlus
S1252	LSRHSsPTEER		PhosphoSitePlus
S63	DSACKsPESDL		PhosphoSitePlus
T1494	KNNAQtMPGEV	Pkinase	PhosphoSitePlus
T458	ELESStDESEE	Anophelin	PhosphoSitePlus
S1268	PRGDSsGSTRR		PhosphoSitePlus
S456	LKELEsSTDES		HPRD
S431	VFEIPsPRPSK	Anophelin	PhosphoSitePlus
S173	DSVGGsLPKKS		PhosphoSitePlus
S499	LERLEsEDDSL		PhosphoSitePlus; HPRD

M3K4_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000375986	R558C	COSMIC	Hepatocellular Carcinoma	21822264
ENSP00000375986	D483Y	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000375986	D575Y	Ding2008	Lung Cancer	18948947
ENSP00000375986	E1608K	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000375986	G505V	Ding2008	Lung Cancer	18948947
ENSP00000375986	E1413Q	HPI	Ovarian Cancer	17344846
ENSP00000375986	P64S	COSMIC	Gastric Cancer	21097718
ENSP00000375986	D565Y	Ding2008	Lung Cancer	18948947

M3K4_HUMAN is not differential expressed protein.

M3K4_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
GA45G_HUMAN	M3K4_HUMAN	other	KEGG

KEGG Pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0048471	perinuclear region of cytoplasm	IEA	cellular_component
GO:0007254	JNK cascade	TAS	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0007243	intracellular protein kinase cascade	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0000186	activation of MAPKK activity	TAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0043507	positive regulation of JUN kinase activity	IEA	biological_process
GO:0010468	regulation of gene expression	IEA	biological_process
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular_function
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0060718	chorionic trophoblast cell differentiation	IEA	biological_process
GO:0019100	male germ-line sex determination	IEA	biological_process
GO:0006950	response to stress	TAS	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0001890	placenta development	IEA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network