Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K12_HUMAN
Description:mitogen-activated protein kinase kinase kinase 12 [Source:HGNC Symbol;Acc:6851]
Location:chr12 q13.13
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S634AGDPGsPPPARPhosphoSitePlus
S757SSENPsDGEEGPhosphoSitePlus

Dephosphorylation site
M3K12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000267079E409KHPIBreast Cancer17344846
ENSP00000267079L237FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000267079G690RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
M3K12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K12_HUMANMP2K7_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0030426growth coneIEAcellular_component
GO:0007254JNK cascadeISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationISSbiological_process
GO:0016572histone phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0033267axon partIEAcellular_component
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0016020membraneISScellular_component
GO:0018105peptidyl-serine phosphorylationIEAbiological_process


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