Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LRRF1_HUMAN
Description:leucine rich repeat (in FLII) interacting protein 1 [Source:HGNC Symbol;Acc:6702]
Location:chr2 q37.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T123RGSGDtSISIDDUF2051PhosphoSitePlus
Y274LNNVGyQGPTKDUF2051PhosphoSitePlus
S689DGATQsSPAEPHPRD
T295STGDGtLGRASphosphoELM
S564GEALDsSQKKTPhosphoSitePlus
S68RNTSAsDEDERDUF2051PhosphoSitePlus
T676LADGDtLDFEDPhosphoSitePlus; phosphoELM
S124GSGDTsISIDTDUF2051PhosphoSitePlus
S3AAAQHPRD
T563PVPVEtLKDVKHPRD
S594STDRKsAVEAQHPRD
S618STDRKsAVEAQPhosphoSitePlus; phosphoELM
S766RKALDsNSLENPhosphoSitePlus
S733LPEHEsPSQDIPhosphoSitePlus; phosphoELM
S290LNALKsTGDGTDUF2051PhosphoSitePlus
S104NMPGLsAATLADUF2051PhosphoSitePlus
S541EALDSsQKKTKHPRD
T295STGDGtLGRASDUF2051PhosphoSitePlus
S16EIDCLsPEAQKPhosphoSitePlus; HPRD; phosphoELM
S775ENDDLsAPGREPhosphoSitePlus
S663DTVQSsGPRAGHPRD
S565EALDSsQKKTKPhosphoSitePlus
S116LGGTSsRRGSGHPRD; phosphoELM
S126GDTSIsIDTEAHPRD; phosphoELM
S614KIAAEsSENVDHPRD
T2PAAAHPRD
T687KIDGAtQSSPAHPRD
S521TEVPGsPAGTEPhosphoSitePlus; phosphoELM
S768ALDSNsLENDDPhosphoSitePlus
T596VKKELtYQNTDPhosphoSitePlus
Y451SDDTVyHDDKCDUF2051PhosphoSitePlus
S690GATQSsPAEPKHPRD
S709LPEHEsPSQDIHPRD
S713DGATQsSPAEPPhosphoSitePlus; phosphoELM
T114ASLGGtSSRRGDUF2051PhosphoSitePlus
S115SLGGTsSRRGSDUF2051PhosphoSitePlus
S744ALDSNsLENDDHPRD
T403DDRTRtPLEPSDUF2051PhosphoSitePlus
T652LADGDtLDFEDHPRD
S116LGGTSsRRGSGDUF2051PhosphoSitePlus
S124GSGDTsISIDTHPRD; phosphoELM
S531PDEEKsDQQGEHPRD
T123RGSGDtSISIDHPRD; phosphoELM
Y597KKELTyQNTDLPhosphoSitePlus
S581NKKKKsPVPVEPhosphoSitePlus; phosphoELM
S120SSRRGsGDTSIDUF2051PhosphoSitePlus
Y190KTNFMyQVDTLDUF2051PhosphoSitePlus
T711KIDGAtQSSPAPhosphoSitePlus
S711EHESPsQDISDHPRD
S540GEALDsSQKKTHPRD
S497TEVPGsPAGTEHPRD
S557NKKKKsPVPVEHPRD
S555PDEEKsDQQGEPhosphoSitePlus
S742RKALDsNSLENHPRD
S735EHESPsQDISDPhosphoSitePlus; phosphoELM
T114ASLGGtSSRRGHPRD; phosphoELM
S115SLGGTsSRRGSHPRD; phosphoELM
S120SSRRGsGDTSIHPRD; phosphoELM
T271STGDGtLGRASHPRD
S110AATLAsLGGTSDUF2051PhosphoSitePlus
T291NALKStGDGTLDUF2051PhosphoSitePlus
S714GATQSsPAEPKPhosphoSitePlus; phosphoELM; SysPTM
S687DTVQSsGPRAGphosphoELM

Dephosphorylation site
LRRF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000375857S68CSjoblom2006, HPIBreast Cancer16959974
ENSP00000244815Q634XBIOMARTBreast Cancer21930507, 21930502
ENSP00000375857V591ACOSMICOvarian Cancer21720365
ENSP00000244815S68CSjoblom2006, COSMICBreast Cancer16959974
ENSP00000244815V567ACOSMICOvarian Cancer21720365
ENSP00000244815Q634*COSMICBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000375857Gastric CancerMetastasiscell lineDown0.5917022644
ENSP00000375857Gastric CancerMetastasiscell lineDown0.5917022644
ENSP00000375857Breast CancerNormal vs. CancertissueUp0.4620739354

Hyperphosphorylation site
LRRF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANLRRF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANLRRF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANLRRF1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANLRRF1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
LRRF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005856cytoskeletonTAScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusNAScellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0003725double-stranded RNA bindingTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process


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