| UniProt/SwissProt ID: | LRRF1_HUMAN |
| Description: | leucine rich repeat (in FLII) interacting protein 1 [Source:HGNC Symbol;Acc:6702] |
| Location: | chr2 q37.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T123 | RGSGDtSISID | DUF2051 | PhosphoSitePlus |
| Y274 | LNNVGyQGPTK | DUF2051 | PhosphoSitePlus |
| S689 | DGATQsSPAEP | HPRD | |
| T295 | STGDGtLGRAS | phosphoELM | |
| S564 | GEALDsSQKKT | PhosphoSitePlus | |
| S68 | RNTSAsDEDER | DUF2051 | PhosphoSitePlus |
| T676 | LADGDtLDFED | PhosphoSitePlus; phosphoELM | |
| S124 | GSGDTsISIDT | DUF2051 | PhosphoSitePlus |
| S3 | AAAQ | HPRD | |
| T563 | PVPVEtLKDVK | HPRD | |
| S594 | STDRKsAVEAQ | HPRD | |
| S618 | STDRKsAVEAQ | PhosphoSitePlus; phosphoELM | |
| S766 | RKALDsNSLEN | PhosphoSitePlus | |
| S733 | LPEHEsPSQDI | PhosphoSitePlus; phosphoELM | |
| S290 | LNALKsTGDGT | DUF2051 | PhosphoSitePlus |
| S104 | NMPGLsAATLA | DUF2051 | PhosphoSitePlus |
| S541 | EALDSsQKKTK | HPRD | |
| T295 | STGDGtLGRAS | DUF2051 | PhosphoSitePlus |
| S16 | EIDCLsPEAQK | PhosphoSitePlus; HPRD; phosphoELM | |
| S775 | ENDDLsAPGRE | PhosphoSitePlus | |
| S663 | DTVQSsGPRAG | HPRD | |
| S565 | EALDSsQKKTK | PhosphoSitePlus | |
| S116 | LGGTSsRRGSG | HPRD; phosphoELM | |
| S126 | GDTSIsIDTEA | HPRD; phosphoELM | |
| S614 | KIAAEsSENVD | HPRD | |
| T2 | PAAA | HPRD | |
| T687 | KIDGAtQSSPA | HPRD | |
| S521 | TEVPGsPAGTE | PhosphoSitePlus; phosphoELM | |
| S768 | ALDSNsLENDD | PhosphoSitePlus | |
| T596 | VKKELtYQNTD | PhosphoSitePlus | |
| Y451 | SDDTVyHDDKC | DUF2051 | PhosphoSitePlus |
| S690 | GATQSsPAEPK | HPRD | |
| S709 | LPEHEsPSQDI | HPRD | |
| S713 | DGATQsSPAEP | PhosphoSitePlus; phosphoELM | |
| T114 | ASLGGtSSRRG | DUF2051 | PhosphoSitePlus |
| S115 | SLGGTsSRRGS | DUF2051 | PhosphoSitePlus |
| S744 | ALDSNsLENDD | HPRD | |
| T403 | DDRTRtPLEPS | DUF2051 | PhosphoSitePlus |
| T652 | LADGDtLDFED | HPRD | |
| S116 | LGGTSsRRGSG | DUF2051 | PhosphoSitePlus |
| S124 | GSGDTsISIDT | HPRD; phosphoELM | |
| S531 | PDEEKsDQQGE | HPRD | |
| T123 | RGSGDtSISID | HPRD; phosphoELM | |
| Y597 | KKELTyQNTDL | PhosphoSitePlus | |
| S581 | NKKKKsPVPVE | PhosphoSitePlus; phosphoELM | |
| S120 | SSRRGsGDTSI | DUF2051 | PhosphoSitePlus |
| Y190 | KTNFMyQVDTL | DUF2051 | PhosphoSitePlus |
| T711 | KIDGAtQSSPA | PhosphoSitePlus | |
| S711 | EHESPsQDISD | HPRD | |
| S540 | GEALDsSQKKT | HPRD | |
| S497 | TEVPGsPAGTE | HPRD | |
| S557 | NKKKKsPVPVE | HPRD | |
| S555 | PDEEKsDQQGE | PhosphoSitePlus | |
| S742 | RKALDsNSLEN | HPRD | |
| S735 | EHESPsQDISD | PhosphoSitePlus; phosphoELM | |
| T114 | ASLGGtSSRRG | HPRD; phosphoELM | |
| S115 | SLGGTsSRRGS | HPRD; phosphoELM | |
| S120 | SSRRGsGDTSI | HPRD; phosphoELM | |
| T271 | STGDGtLGRAS | HPRD | |
| S110 | AATLAsLGGTS | DUF2051 | PhosphoSitePlus |
| T291 | NALKStGDGTL | DUF2051 | PhosphoSitePlus |
| S714 | GATQSsPAEPK | PhosphoSitePlus; phosphoELM; SysPTM | |
| S687 | DTVQSsGPRAG | phosphoELM | |
| Dephosphorylation site |
| LRRF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000375857 | S68C | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000244815 | Q634X | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000375857 | V591A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000244815 | S68C | Sjoblom2006, COSMIC | Breast Cancer | 16959974 | ENSP00000244815 | V567A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000244815 | Q634* | COSMIC | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000375857 | Gastric Cancer | Metastasis | cell line | Down | 0.59 | 17022644 | ENSP00000375857 | Gastric Cancer | Metastasis | cell line | Down | 0.59 | 17022644 | ENSP00000375857 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.46 | 20739354 |
| Hyperphosphorylation site |
| LRRF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | LRRF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCD_HUMAN | LRRF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | LRRF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | LRRF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| LRRF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005856 | cytoskeleton | TAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0003725 | double-stranded RNA binding | TAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |