Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LPHN1_HUMAN
Description:latrophilin 1 [Source:HGNC Symbol;Acc:20973]
Location:chr19 p13.12
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1036LKPDSsRLDNIHPRD
S1040VLKPDsSRLDN7tm_2PhosphoSitePlus
Y967RTKYYyLGGYC7tm_2; TMPhosphoSitePlus
S1035VLKPDsSRLDNHPRD
Y131YDCVPyKVEQKPhosphoSitePlus
Y1446PSHEGyLAAPGHPRD
S1034MIRSSsVLKPD7tm_2PhosphoSitePlus
S1032HKMIRsSSVLKHPRD
S1351LPRAQsVLYQSLatrophilinPhosphoSitePlus
S1164KQTESsFMAGDLatrophilinPhosphoSitePlus
Y616RTCKDyIKAVVDUF3497PhosphoSitePlus
S1041LKPDSsRLDNIHPRD
Y1441PLQGYyQVRRPLatrophilinPhosphoSitePlus
Y1440NPLQGyYQVRRLatrophilinPhosphoSitePlus
T1156RMWNDtVRKQTLatrophilinPhosphoSitePlus
S1041LKPDSsRLDNI7tm_2PhosphoSitePlus
S1027HKMIRsSSVLKHPRD
S1356SVLYQsDLDESLatrophilinPhosphoSitePlus
Y1435NPLQGyYQVRRHPRD
S1040VLKPDsSRLDNHPRD
S1129GGTHGsLKTSALatrophilinPhosphoSitePlus
Y126YLEVQyDCVPYGal_LectinPhosphoSitePlus
T1173GDINStPTLNRLatrophilinPhosphoSitePlus
Y121PGTYKyLEVQYGal_LectinPhosphoSitePlus
Y1385GRDSLyASGANLatrophilinPhosphoSitePlus
Y236RNIVKyDLRTROLFPhosphoSitePlus
S1028KMIRSsSVLKPHPRD
S1033KMIRSsSVLKPHPRD
Y1451PSHEGyLAAPGHPRD
Y989IDYRSyGTEKA7tm_2PhosphoSitePlus
Y966SRTKYyYLGGY7tm_2; TMPhosphoSitePlus
Y1337EIELLyKALEELatrophilinPhosphoSitePlus
Y1440NPLQGyYQVRRHPRD; phosphoELM

Dephosphorylation site
LPHN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340688A800DCOSMICOvarian Cancer21720365
ENSP00000340688I1170MCOSMICOvarian Cancer21720365
ENSP00000340688V1095ICOSMICHead and Neck Cancer21798893
ENSP00000340688A73DCOSMICLung Cancer20668451
ENSP00000340688V696LCOSMICLung Cancer20668451

Differential expressed protein
LPHN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LPHN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SHAN1_HUMANLPHN1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
LPHN1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045202synapseISScellular_component
GO:0042734presynaptic membraneISScellular_component
GO:0016524latrotoxin receptor activityISSmolecular_function
GO:0007157heterophilic cell-cell adhesionISSbiological_process
GO:0090129positive regulation of synapse maturationISSbiological_process
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0035584calcium-mediated signaling using intracellular calISSbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneISScellular_component
GO:0030426growth coneISScellular_component
GO:0043005neuron projectionISScellular_component
GO:0016020membraneIEAcellular_component
GO:0050839cell adhesion molecule bindingISSmolecular_function
GO:0030054cell junctionIEAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0030246carbohydrate bindingIEAmolecular_function
GO:0030424axonISScellular_component