Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LIMA1_HUMAN
Description:LIM domain and actin binding 1 [Source:HGNC Symbol;Acc:24636]
Location:chr12 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S15QWTSLsLRVTAPhosphoSitePlus; HPRD; phosphoELM
Y437LHGRIyCKPHFLIMPhosphoSitePlus
S279YQAAVsKQSSSPhosphoSitePlus; HPRD
S350DSQVKsEVQQPPhosphoSitePlus
S110PAEVTsHAASGPhosphoSitePlus
S365PLSPDsRASSLPhosphoSitePlus; HPRD; phosphoELM
S336SLAVRsTPAEDHPRD
S604STSVKsPKTVSPhosphoSitePlus; HPRD; phosphoELM
S373SSLSEsSPPKAPhosphoSitePlus; HPRD
S132RSRLRsPPEALPhosphoSitePlus; HPRD; phosphoELM
T109PPAEVtSHAASPhosphoSitePlus
S625EQSEEsVGGRVHPRD
S609SPKTVsPPIRKPhosphoSitePlus; HPRD; phosphoELM
S114TSHAAsGAKADPhosphoSitePlus
T600ASFQStSVKSPPhosphoSitePlus
Y429LSLGTyASLHGLIMPhosphoSitePlus
S741VVKELsVEEQIPhosphoSitePlus; HPRD
S692DEDDNsFLKQQPhosphoSitePlus; HPRD; phosphoELM
T68HFRKGtLTVLKPhosphoSitePlus
S601SFQSTsVKSPKPhosphoSitePlus; HPRD; phosphoELM
S374SLSESsPPKAMPhosphoSitePlus; HPRD; phosphoELM
T536AWPPPtELGSSPhosphoSitePlus
S431LGTYAsLHGRILIMPhosphoSitePlus
Y287SSSTNyTNELKPhosphoSitePlus
T714SFVDNtFAEEFPhosphoSitePlus
Y751IKRNRyYDEDEPhosphoSitePlus
S331SANENsLAVRSPhosphoSitePlus; HPRD
S698FLKQQsPQEPKPhosphoSitePlus; HPRD; phosphoELM
S726TQNQKsQDVELPhosphoSitePlus; HPRD
Y752KRNRYyDEDEDPhosphoSitePlus
S686ENGADsDEDDNPhosphoSitePlus; HPRD; phosphoELM
S619KGWSMsEQSEEHPRD; phosphoELM
S228KISENsYSLDDPhosphoSitePlus; HPRD; phosphoELM
S346DDSRDsQVKSEPhosphoSitePlus
Y190GKIEKyNVPLNPhosphoSitePlus
T607VKSPKtVSPPIHPRD; phosphoELM
S588SLKERsRPFTVPhosphoSitePlus; HPRD
S369DSRASsLSESSPhosphoSitePlus; HPRD; phosphoELM
S4__MESsPFNRRPhosphoSitePlus
S582KLRRSsSLKERPhosphoSitePlus
S371RASSLsESSPPHPRD
S709SLNWSsFVDNTPhosphoSitePlus; HPRD
S599AASFQsTSVKSPhosphoSitePlus; HPRD; phosphoELM
S343PAEDDsRDSQVPhosphoSitePlus; HPRD
S263ELPRLsETSIKPhosphoSitePlus; HPRD
S4FNRRHPRD
S583LRRSSsLKERSPhosphoSitePlus
T428KLSLGtYASLHLIMPhosphoSitePlus
T57KKRSNtENLSQPhosphoSitePlus
Y274DRMAKyQAAVSPhosphoSitePlus
S490RETPHsPGVEDPhosphoSitePlus; HPRD; phosphoELM
S230SENSYsLDDLEPhosphoSitePlus; HPRD; phosphoELM
S540PTELGsSGSALHPRD
T487ANAREtPHSPGPhosphoSitePlus; HPRD; phosphoELM
S368PDSRAsSLSESPhosphoSitePlus; HPRD
Y41EIFSKyQKAAEPhosphoSitePlus
Y452KSKGNyDEGFGPhosphoSitePlus
T337LAVRStPAEDDPhosphoSitePlus; HPRD
Y229ISENSySLDDLPhosphoSitePlus; HPRD; phosphoELM
S642ENAKAsKKNGNPhosphoSitePlus
S362HPKPLsPDSRAPhosphoSitePlus; HPRD; phosphoELM
S55MEKKRsNTENLPhosphoSitePlus
S266RLSETsIKDRMHPRD
S225SGRKIsENSYSPhosphoSitePlus; HPRD; phosphoELM
S617IRKGWsMSEQSPhosphoSitePlus; HPRD; phosphoELM
S622SMSEQsEESVGHPRD; phosphoELM
T592RSRPFtVAASFPhosphoSitePlus; HPRD

Dephosphorylation site
LIMA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340184R9WCOSMICOvarian Cancer21720365
ENSP00000340184S85FBIOMARTBreast Cancer21930507, 21930502
ENSP00000340184L679VBIOMARTBreast Cancer21930507, 21930502
ENSP00000340184S266PCOSMICSkin Cancer21984974
ENSP00000340184T245ACOSMICSkin Cancer21984974
ENSP00000378400S85FBIOMARTBreast Cancer21930507, 21930502
ENSP00000378400L680VBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000340184Oral CancerNormal vs. CancertissueUp4.319297561

Hyperphosphorylation site
LIMA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2D_HUMANLIMA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
LIMA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031529ruffle organizationIDAbiological_process
GO:0015629actin cytoskeletonIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0051015actin filament bindingIDAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003785actin monomer bindingIDAmolecular_function
GO:0015629actin cytoskeletonIDAcellular_component
GO:0051017actin filament bundle assemblyIDAbiological_process
GO:0001725stress fiberIDAcellular_component
GO:0005925focal adhesionIDAcellular_component
GO:0030835negative regulation of actin filament depolymerizaIDAbiological_process
GO:0005737cytoplasmIDAcellular_component


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