Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LGR4_HUMAN
Description:leucine-rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol;Acc:13299]
Location:chr11 p14.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y848YDCGMySHLQGPhosphoSitePlus
Y908SAHSDyADEEDPhosphoSitePlus
Y942FPLVRyAYNLPPhosphoSitePlus
S333GTKISsIPNNLHPRD
Y932GRACFyQSRGFPhosphoSitePlus
Y944LVRYAyNLPRVPhosphoSitePlus
S616WWETGsGCKVA7tm_1PhosphoSitePlus
S880LIKSHsCPALAPhosphoSitePlus
S332TGTKIsSIPNNHPRD

Dephosphorylation site
LGR4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368516R941LCOSMICOvarian Cancer21720365
ENSP00000368516V708IBIOMARTBreast Cancer21930507, 21930502
ENSP00000368516H293YBIOMARTBreast Cancer21930507, 21930502
ENSP00000368516G266VBIOMARTBreast Cancer21930507, 21930502
ENSP00000368516K807NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000368516Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
LGR4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RSPO1_HUMANLGR4_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
LGR4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0072282metanephric nephron tubule morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0090190positive regulation of branching involved in ureteIEAbiological_process
GO:0035239tube morphogenesisIEAbiological_process
GO:0072202cell differentiation involved in metanephros develIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0072224metanephric glomerulus developmentIEAbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0061290canonical Wnt receptor signaling pathway involved IEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0050673epithelial cell proliferationIEAbiological_process
GO:0030539male genitalia developmentIEAbiological_process
GO:0016500protein-hormone receptor activityIEAmolecular_function


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