Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LEP_HUMAN
Description:leptin [Source:HGNC Symbol;Acc:6553]
Location:chr7 q32.1
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T48NDISHtQSVSSLeptinPhosphoSitePlus

Dephosphorylation site
LEP_HUMAN do not have dephosphorylation site.

Mutation site
LEP_HUMAN do not have mutation site.

Differential expressed protein
LEP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LEP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LEP_HUMANOBRG_HUMANligand -> receptorHPMR
LEP_HUMANOBRG_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04920Adipocytokine signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046427positive regulation of JAK-STAT cascadeIEAbiological_process
GO:0050901leukocyte tethering or rollingIEAbiological_process
GO:0042755eating behaviorIEAbiological_process
GO:0070093negative regulation of glucagon secretionIEAbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0033210leptin-mediated signaling pathwayIEAbiological_process
GO:0007623circadian rhythmIEAbiological_process
GO:0008343adult feeding behaviorIEAbiological_process
GO:0060612adipose tissue developmentIEAbiological_process
GO:0033686positive regulation of luteinizing hormone secretiIEAbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0046881positive regulation of follicle-stimulating hormonIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0007565female pregnancyIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0008217regulation of blood pressureIEAbiological_process
GO:0030300regulation of intestinal cholesterol absorptionIEAbiological_process
GO:0001542ovulation from ovarian follicleIEAbiological_process
GO:0009062fatty acid catabolic processIEAbiological_process
GO:0006112energy reserve metabolic processIEAbiological_process
GO:0001819positive regulation of cytokine productionIEAbiological_process
GO:2000366positive regulation of STAT protein import into nuIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0048639positive regulation of developmental growthIDAbiological_process
GO:0051428peptide hormone receptor bindingIEAmolecular_function
GO:0032868response to insulin stimulusIEAbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0050810regulation of steroid biosynthetic processIEAbiological_process
GO:2000491positive regulation of hepatic stellate cell activIEAbiological_process
GO:0042307positive regulation of protein import into nucleusIEAbiological_process
GO:0006111regulation of gluconeogenesisIEAbiological_process
GO:0001890placenta developmentIDAbiological_process
GO:0008206bile acid metabolic processIEAbiological_process
GO:0042445hormone metabolic processIEAbiological_process
GO:0071298cellular response to L-ascorbic acidIEAbiological_process
GO:0009892negative regulation of metabolic processIEAbiological_process
GO:0021954central nervous system neuron developmentIEAbiological_process
GO:0061037negative regulation of cartilage developmentIEAbiological_process
GO:0046628positive regulation of insulin receptor signaling IEAbiological_process
GO:0030073insulin secretionIEAbiological_process
GO:0032099negative regulation of appetiteISSbiological_process
GO:0007260tyrosine phosphorylation of STAT proteinIEAbiological_process
GO:0019222regulation of metabolic processIEAbiological_process
GO:0006114glycerol biosynthetic processIEAbiological_process
GO:0005179hormone activityIEAmolecular_function
GO:2000486negative regulation of glutamine transportIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0060587regulation of lipoprotein lipid oxidationIEAbiological_process
GO:0033197response to vitamin EIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0032099negative regulation of appetiteIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0008343adult feeding behaviorISSbiological_process
GO:0005615extracellular spaceISScellular_component
GO:0050796regulation of insulin secretionIEAbiological_process
GO:0045639positive regulation of myeloid cell differentiatioIEAbiological_process
GO:0043270positive regulation of ion transportIEAbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0002021response to dietary excessIEAbiological_process
GO:0045906negative regulation of vasoconstrictionIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0035630bone mineralization involved in bone maturationIEAbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process