Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LDLR_HUMAN
Description:low density lipoprotein receptor [Source:HGNC Symbol;Acc:6547]
Location:chr19 p13.2
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S397CKAVGsIAYLFHPRD
Y465HGVSSyDTVISLdl_recept_bPhosphoSitePlus
Y847QDGYSyPSRQMPhosphoSitePlus; HPRD
S846NQDGYsYPSRQPhosphoSitePlus
Y845HNQDGySYPSRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y828FDNPVyQKTTEPhosphoSitePlus
S517FRENGsKPRAILdl_recept_bPhosphoSitePlus
T404AYLFFtNRHEVHPRD
S470YDTVIsRDIQALdl_recept_bPhosphoSitePlus

Dephosphorylation site
LDLR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000454071P848LTCGAOvarian Cancer21720365, 18772890
ENSP00000397829G468SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000454071N297STCGAOvarian Cancer21720365, 18772890

Differential expressed protein
LDLR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LDLR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
APOE_HUMANLDLR_HUMANligand -> receptorHPMR
PLF4_HUMANLDLR_HUMANligand -> receptorHPMR
APOB_HUMANLDLR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04976Bile secretion
hsa04144Endocytosis
hsa05160Hepatitis C
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005764lysosomeIDAcellular_component
GO:0070508cholesterol importISSbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0006898receptor-mediated endocytosisTASbiological_process
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0010899regulation of phosphatidylcholine catabolic procesISSbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005769early endosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0034383low-density lipoprotein particle clearanceIMPbiological_process
GO:0030669clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0009897external side of plasma membraneIDAcellular_component
GO:0005041low-density lipoprotein receptor activityIDAmolecular_function
GO:0030169low-density lipoprotein particle bindingIEAmolecular_function
GO:0006629lipid metabolic processTASbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0030299intestinal cholesterol absorptionIMPbiological_process
GO:0006897endocytosisTASbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0042632cholesterol homeostasisIMPbiological_process
GO:0034362low-density lipoprotein particleIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0001948glycoprotein bindingIPImolecular_function
GO:0005770late endosomeIDAcellular_component
GO:0030301cholesterol transportIMPbiological_process
GO:0030229very-low-density lipoprotein particle receptor actIDAmolecular_function
GO:0042159lipoprotein catabolic processIEAbiological_process
GO:0005905coated pitIDAcellular_component
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0015914phospholipid transportISSbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0010867positive regulation of triglyceride biosynthetic pISSbiological_process


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