Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LCAT_HUMAN
Description:lecithin-cholesterol acyltransferase [Source:HGNC Symbol;Acc:6522]
Location:chr16 q22.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S205FLIGHsLGCLHphosphoELM
S205FLIGHsLGCLHLACTPhosphoSitePlus
Y213CLHLLyFLLRQLACTPhosphoSitePlus

Dephosphorylation site
LCAT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264005T298ACOSMICOvarian Cancer21720365

Differential expressed protein
LCAT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LCAT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANLCAT_HUMANTF -> target geneTRANSFAC
SP3_HUMANLCAT_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
LCAT_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042632cholesterol homeostasisIDAbiological_process
GO:0004607phosphatidylcholine-sterol O-acyltransferase activIEAmolecular_function
GO:0008203cholesterol metabolic processIDAbiological_process
GO:0034364high-density lipoprotein particleIDAcellular_component
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0034435cholesterol esterificationIDAbiological_process
GO:0034372very-low-density lipoprotein particle remodelingIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0042158lipoprotein biosynthetic processIEAbiological_process
GO:0090107regulation of high-density lipoprotein particle asIEAbiological_process
GO:0008374O-acyltransferase activityIEAmolecular_function
GO:0006644phospholipid metabolic processIDAbiological_process
GO:0034186apolipoprotein A-I bindingIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0030301cholesterol transportIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006629lipid metabolic processIEAbiological_process
GO:0034375high-density lipoprotein particle remodelingIDAbiological_process
GO:0043691reverse cholesterol transportIDAbiological_process
GO:0006656phosphatidylcholine biosynthetic processIDAbiological_process


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