Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LA_HUMAN
Description:Sjogren syndrome antigen B (autoantigen La) [Source:HGNC Symbol;Acc:11316]
Location:chr2 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S366KTKFAsDDEHDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T178QKYKEtDLLILRRM_1PhosphoSitePlus
T302RNKEVtWEVLERRM_3PhosphoSitePlus
S366KTKFAsDDEHDCK2a1(CK2 alphaRegPhos; SysPTM
S325EDQQEsLNKWKRRM_3PhosphoSitePlus
T302RNKEVtWEVLEHPRD; phosphoELM; RegPhos
S325EDQQEsLNKWKHPRD; phosphoELM; RegPhos
T178QKYKEtDLLILHPRD
Y188LFKDDyFAKKNPhosphoSitePlus
S366KTKFAsDDEHDCK2_groupphosphoELM; RegPhos; SysPTM
S366KTKFAsDDEHDCK2_alphaphosphoELM; SysPTM
Y23CHQIEyYFGDFLaPhosphoSitePlus
S94IRRSPsKPLPEPhosphoSitePlus; HPRD; phosphoELM
T362FQGKKtKFASDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T389RAREEtDKEEPPhosphoSitePlus
S92TKIRRsPSKPLPhosphoSitePlus; HPRD; phosphoELM
T379DENGAtGPVKRHPRD
Y104EVTDEyKNDVKPhosphoSitePlus
Y24HQIEYyFGDFNLaPhosphoSitePlus

Dephosphorylation site
LA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260956N199KCOSMICMelanoma21499247
ENSP00000260956F55LCOSMICHead and Neck Cancer21798893
ENSP00000260956Q198KCOSMICMelanoma21499247
ENSP00000260956R196KCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000386636Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000386636Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000386636chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineUp1.320417730
ENSP00000386636Renal CancerNormal vs. CancertissueDown0.2719610612

Hyperphosphorylation site
LA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANLA_HUMANkinase -> substrateRegPhos
CSK21_HUMANLA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05322Systemic lupus erythematosus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000166nucleotide bindingIEAmolecular_function
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0000049tRNA bindingTASmolecular_function
GO:0003729mRNA bindingTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0006396RNA processingIEAbiological_process
GO:0006400tRNA modificationTASbiological_process
GO:0008334histone mRNA metabolic processTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function


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