| UniProt/SwissProt ID: | LA_HUMAN |
| Description: | Sjogren syndrome antigen B (autoantigen La) [Source:HGNC Symbol;Acc:11316] |
| Location: | chr2 q31.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S366 | KTKFAsDDEHD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T178 | QKYKEtDLLIL | RRM_1 | PhosphoSitePlus |
| T302 | RNKEVtWEVLE | RRM_3 | PhosphoSitePlus |
| S366 | KTKFAsDDEHD | CK2a1(CK2 alpha | RegPhos; SysPTM |
| S325 | EDQQEsLNKWK | RRM_3 | PhosphoSitePlus |
| T302 | RNKEVtWEVLE | HPRD; phosphoELM; RegPhos | |
| S325 | EDQQEsLNKWK | HPRD; phosphoELM; RegPhos | |
| T178 | QKYKEtDLLIL | HPRD | |
| Y188 | LFKDDyFAKKN | PhosphoSitePlus | |
| S366 | KTKFAsDDEHD | CK2_group | phosphoELM; RegPhos; SysPTM |
| S366 | KTKFAsDDEHD | CK2_alpha | phosphoELM; SysPTM |
| Y23 | CHQIEyYFGDF | La | PhosphoSitePlus |
| S94 | IRRSPsKPLPE | PhosphoSitePlus; HPRD; phosphoELM | |
| T362 | FQGKKtKFASD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T389 | RAREEtDKEEP | PhosphoSitePlus | |
| S92 | TKIRRsPSKPL | PhosphoSitePlus; HPRD; phosphoELM | |
| T379 | DENGAtGPVKR | HPRD | |
| Y104 | EVTDEyKNDVK | PhosphoSitePlus | |
| Y24 | HQIEYyFGDFN | La | PhosphoSitePlus |
| Dephosphorylation site |
| LA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260956 | N199K | COSMIC | Melanoma | 21499247 | ENSP00000260956 | F55L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000260956 | Q198K | COSMIC | Melanoma | 21499247 | ENSP00000260956 | R196K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000386636 | Gastric Cancer | Metastasis | cell line | Up | 1.8 | 17022644 | ENSP00000386636 | Gastric Cancer | Metastasis | cell line | Up | 1.8 | 17022644 | ENSP00000386636 | chronic myeloid leukemia | Treatment (Imatinib-sensitive vs. Imatinib-resistant) | cell line | Up | 1.3 | 20417730 | ENSP00000386636 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.27 | 19610612 |
| Hyperphosphorylation site |
| LA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | LA_HUMAN | kinase -> substrate | RegPhos |
| CSK21_HUMAN | LA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05322 | Systemic lupus erythematosus |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IEA | cellular_component |
| GO:0000049 | tRNA binding | TAS | molecular_function |
| GO:0003729 | mRNA binding | TAS | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0006396 | RNA processing | IEA | biological_process |
| GO:0006400 | tRNA modification | TAS | biological_process |
| GO:0008334 | histone mRNA metabolic process | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |