| UniProt/SwissProt ID: | LATS2_HUMAN |
| Description: | LATS, large tumor suppressor, homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:6515] |
| Location: | chr13 q12.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S12 | PATTYsGNSRQ | PhosphoSitePlus | |
| Y1038 | PEHAFyEFTFR | Pkinase_C | PhosphoSitePlus |
| S380 | LARRDsLQKPG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T1026 | AWDTLtSPNNK | HPRD; phosphoELM | |
| T690 | ACKVDtHALYA | Pkinase | PhosphoSitePlus |
| S1027 | WDTLTsPNNKH | Pkinase_C | PhosphoSitePlus |
| S829 | YYQKGsHVRQD | HPRD; RegPhos | |
| T9 | KTFPAtTYSGN | PhosphoSitePlus | |
| S408 | PSRTNsFNSHQ | PhosphoSitePlus | |
| S83 | REIRYsLLPFA | Aurora A | phosphoELM |
| T1024 | TKAWDtLTSPN | HPRD; phosphoELM | |
| S83 | REIRYsLLPFA | AurA(STK6 | RegPhos |
| T279 | SFQSKtPPETG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y11 | FPATTySGNSR | PhosphoSitePlus | |
| S83 | REIRYsLLPFA | AurA | RegPhos |
| T1024 | TKAWDtLTSPN | Pkinase_C | PhosphoSitePlus |
| S872 | RCLAHsLVGTP | Pkinase | PhosphoSitePlus |
| T10 | TFPATtYSGNS | PhosphoSitePlus | |
| Y286 | PETGGyASLPT | PhosphoSitePlus | |
| Y1051 | FDDNGyPFRCP | PhosphoSitePlus | |
| Y531 | SKSEQyDLDSL | PhosphoSitePlus | |
| Y82 | LREIRySLLPF | PhosphoSitePlus | |
| Y135 | EAALEyISKMG | UBA | PhosphoSitePlus |
| S446 | LHPVKsVRVLR | PhosphoSitePlus | |
| S83 | REIRYsLLPFA | PhosphoSitePlus | |
| S172 | VTRRPsFEGTG | PhosphoSitePlus | |
| Dephosphorylation site |
| LATS2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000372035 | C953* | Greenman2007 | Ovarian Cancer | 17344846, 18428421 | ENSP00000372035 | D852N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372035 | G909R | BIOMART | Neoplasms by Histologic Type | 21930507, 21930502 | ENSP00000372035 | E1016K | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000372035 | G40E | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| LATS2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LATS2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | LATS2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| LATS2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0090090 | negative regulation of canonical Wnt receptor sign | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0090090 | negative regulation of canonical Wnt receptor sign | IMP | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0035329 | hippo signaling cascade | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0034613 | cellular protein localization | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0030216 | keratinocyte differentiation | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0009755 | hormone-mediated signaling pathway | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0035329 | hippo signaling cascade | IEA | biological_process |
| GO:0046620 | regulation of organ growth | IEA | biological_process |
| GO:0000922 | spindle pole | IDA | cellular_component |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0045736 | negative regulation of cyclin-dependent protein ki | IDA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |