Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LATS2_HUMAN
Description:LATS, large tumor suppressor, homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:6515]
Location:chr13 q12.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S12PATTYsGNSRQPhosphoSitePlus
Y1038PEHAFyEFTFRPkinase_CPhosphoSitePlus
S380LARRDsLQKPGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T1026AWDTLtSPNNKHPRD; phosphoELM
T690ACKVDtHALYAPkinasePhosphoSitePlus
S1027WDTLTsPNNKHPkinase_CPhosphoSitePlus
S829YYQKGsHVRQDHPRD; RegPhos
T9KTFPAtTYSGNPhosphoSitePlus
S408PSRTNsFNSHQPhosphoSitePlus
S83REIRYsLLPFAAurora AphosphoELM
T1024TKAWDtLTSPNHPRD; phosphoELM
S83REIRYsLLPFAAurA(STK6RegPhos
T279SFQSKtPPETGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y11FPATTySGNSRPhosphoSitePlus
S83REIRYsLLPFAAurARegPhos
T1024TKAWDtLTSPNPkinase_CPhosphoSitePlus
S872RCLAHsLVGTPPkinasePhosphoSitePlus
T10TFPATtYSGNSPhosphoSitePlus
Y286PETGGyASLPTPhosphoSitePlus
Y1051FDDNGyPFRCPPhosphoSitePlus
Y531SKSEQyDLDSLPhosphoSitePlus
Y82LREIRySLLPFPhosphoSitePlus
Y135EAALEyISKMGUBAPhosphoSitePlus
S446LHPVKsVRVLRPhosphoSitePlus
S83REIRYsLLPFAPhosphoSitePlus
S172VTRRPsFEGTGPhosphoSitePlus

Dephosphorylation site
LATS2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000372035C953*Greenman2007Ovarian Cancer17344846, 18428421
ENSP00000372035D852NBIOMARTBreast Cancer21930507, 21930502
ENSP00000372035G909RBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000372035E1016KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000372035G40EGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
LATS2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LATS2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANLATS2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
LATS2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0035329hippo signaling cascadeIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0034613cellular protein localizationIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIDAbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0009755hormone-mediated signaling pathwayIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0035329hippo signaling cascadeIEAbiological_process
GO:0046620regulation of organ growthIEAbiological_process
GO:0000922spindle poleIDAcellular_component
GO:0007067mitosisIEAbiological_process
GO:0045736negative regulation of cyclin-dependent protein kiIDAbiological_process
GO:0005829cytosolTAScellular_component


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