Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LAMC1_HUMAN
Description:laminin, gamma 1 (formerly LAMB2) [Source:HGNC Symbol;Acc:6492]
Location:chr1 q25.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1275SVAQLsPLDSEPhosphoSitePlus
T166AIYKRtREDGPLaminin_NPhosphoSitePlus
S159TSRPEsFAIYKLaminin_NPhosphoSitePlus
T185GSCENtYSKANHPRD
T196RGFIRtGGDEQLaminin_NPhosphoSitePlus
Y1307QKLKDyEDLREPhosphoSitePlus
T166AIYKRtREDGPHPRD
S159TSRPEsFAIYKHPRD
S181QYYSGsCENTYHPRD
T1541NEIEGtLNKAKPhosphoSitePlus; SysPTM
S179PYQYYsGSCENHPRD
Y413TQCDSyGRCSCLaminin_EGFPhosphoSitePlus
Y667ERSAGyLDDVTHPRD
T216DISPLtGGNVALaminin_NPhosphoSitePlus
S187CENTYsKANRGHPRD
S664TYSERsAGYLDHPRD
S1493MAGMAsQAAQEPhosphoSitePlus
S675DVTLAsARPGPHPRD
S210CTDEFsDISPLLaminin_NPhosphoSitePlus
S1559LDRKVsDLENEPhosphoSitePlus
S181QYYSGsCENTYLaminin_NPhosphoSitePlus

Dephosphorylation site
LAMC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000258341R1116HSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000258341P327RTCGAOvarian Cancer21720365, 18772890
ENSP00000258341Y1307*COSMICRenal Cancer20054297
ENSP00000258341D835ETCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000258341P327RCOSMICOvarian Cancer21720365
ENSP00000258341P214LCOSMICSkin Cancer21984974
ENSP00000258341E1326*BIOMARTBreast Cancer21930507, 21930502
ENSP00000258341G870RBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000258341K1594TTCGAOvarian Cancer21720365, 18772890
ENSP00000258341C370*BIOMARTBreast Cancer21930507, 21930502
ENSP00000258341K318NCOSMICHead and Neck Cancer21798893
ENSP00000258341R359CCOSMICSkin Cancer21984974
ENSP00000258341R1116HHPIColorectal Cancer16959974
ENSP00000258341K1594TCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000258341hepatitis B virusNormal vs. CancertissueUp2.814726492
ENSP00000258341Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000258341Breast CancerNormal vs. CancertissueDown0.6720739354
ENSP00000258341Breast CancerNormal vs. CancertissueDown0.6720739354

Hyperphosphorylation site
LAMC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LAMC1_HUMANRSSA_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05020Prion diseases
hsa04512ECM-receptor interaction
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0022617extracellular matrix disassemblyIMPbiological_process
GO:0016477cell migrationIMPbiological_process
GO:0034446substrate adhesion-dependent cell spreadingIDAbiological_process
GO:0043259laminin-10 complexIEAcellular_component
GO:0005615extracellular spaceNAScellular_component
GO:0005605basal laminaIEAcellular_component
GO:0005604basement membraneIEAcellular_component
GO:0005604basement membraneIDAcellular_component
GO:0043260laminin-11 complexTAScellular_component
GO:0043208glycosphingolipid bindingIEAmolecular_function
GO:0043259laminin-10 complexTAScellular_component
GO:0031581hemidesmosome assemblyIMPbiological_process
GO:0005606laminin-1 complexNAScellular_component
GO:0031175neuron projection developmentIEAbiological_process
GO:0005201extracellular matrix structural constituentIMPmolecular_function
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0007492endoderm developmentTASbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0050679positive regulation of epithelial cell proliferatiTASbiological_process
GO:0006461protein complex assemblyIDAbiological_process
GO:0007155cell adhesionIDAbiological_process


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