| UniProt/SwissProt ID: | LAMC1_HUMAN |
| Description: | laminin, gamma 1 (formerly LAMB2) [Source:HGNC Symbol;Acc:6492] |
| Location: | chr1 q25.3 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1275 | SVAQLsPLDSE | PhosphoSitePlus | |
| T166 | AIYKRtREDGP | Laminin_N | PhosphoSitePlus |
| S159 | TSRPEsFAIYK | Laminin_N | PhosphoSitePlus |
| T185 | GSCENtYSKAN | HPRD | |
| T196 | RGFIRtGGDEQ | Laminin_N | PhosphoSitePlus |
| Y1307 | QKLKDyEDLRE | PhosphoSitePlus | |
| T166 | AIYKRtREDGP | HPRD | |
| S159 | TSRPEsFAIYK | HPRD | |
| S181 | QYYSGsCENTY | HPRD | |
| T1541 | NEIEGtLNKAK | PhosphoSitePlus; SysPTM | |
| S179 | PYQYYsGSCEN | HPRD | |
| Y413 | TQCDSyGRCSC | Laminin_EGF | PhosphoSitePlus |
| Y667 | ERSAGyLDDVT | HPRD | |
| T216 | DISPLtGGNVA | Laminin_N | PhosphoSitePlus |
| S187 | CENTYsKANRG | HPRD | |
| S664 | TYSERsAGYLD | HPRD | |
| S1493 | MAGMAsQAAQE | PhosphoSitePlus | |
| S675 | DVTLAsARPGP | HPRD | |
| S210 | CTDEFsDISPL | Laminin_N | PhosphoSitePlus |
| S1559 | LDRKVsDLENE | PhosphoSitePlus | |
| S181 | QYYSGsCENTY | Laminin_N | PhosphoSitePlus |
| Dephosphorylation site |
| LAMC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258341 | R1116H | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000258341 | P327R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000258341 | Y1307* | COSMIC | Renal Cancer | 20054297 | ENSP00000258341 | D835E | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000258341 | P327R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000258341 | P214L | COSMIC | Skin Cancer | 21984974 | ENSP00000258341 | E1326* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000258341 | G870R | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000258341 | K1594T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000258341 | C370* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000258341 | K318N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000258341 | R359C | COSMIC | Skin Cancer | 21984974 | ENSP00000258341 | R1116H | HPI | Colorectal Cancer | 16959974 | ENSP00000258341 | K1594T | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000258341 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 2.8 | 14726492 | ENSP00000258341 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | ENSP00000258341 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.67 | 20739354 | ENSP00000258341 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.67 | 20739354 |
| Hyperphosphorylation site |
| LAMC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LAMC1_HUMAN | RSSA_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04510 | Focal adhesion |
| hsa05146 | Amoebiasis |
| hsa05145 | Toxoplasmosis |
| hsa05020 | Prion diseases |
| hsa04512 | ECM-receptor interaction |
| hsa05200 | Pathways in cancer |
| hsa05222 | Small cell lung cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0022617 | extracellular matrix disassembly | IMP | biological_process |
| GO:0016477 | cell migration | IMP | biological_process |
| GO:0034446 | substrate adhesion-dependent cell spreading | IDA | biological_process |
| GO:0043259 | laminin-10 complex | IEA | cellular_component |
| GO:0005615 | extracellular space | NAS | cellular_component |
| GO:0005605 | basal lamina | IEA | cellular_component |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0005604 | basement membrane | IDA | cellular_component |
| GO:0043260 | laminin-11 complex | TAS | cellular_component |
| GO:0043208 | glycosphingolipid binding | IEA | molecular_function |
| GO:0043259 | laminin-10 complex | TAS | cellular_component |
| GO:0031581 | hemidesmosome assembly | IMP | biological_process |
| GO:0005606 | laminin-1 complex | NAS | cellular_component |
| GO:0031175 | neuron projection development | IEA | biological_process |
| GO:0005201 | extracellular matrix structural constituent | IMP | molecular_function |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0007492 | endoderm development | TAS | biological_process |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0050679 | positive regulation of epithelial cell proliferati | TAS | biological_process |
| GO:0006461 | protein complex assembly | IDA | biological_process |
| GO:0007155 | cell adhesion | IDA | biological_process |