| UniProt/SwissProt ID: | LAMA2_HUMAN |
| Description: | laminin, alpha 2 [Source:HGNC Symbol;Acc:6482] |
| Location: | chr6 q22.33 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y2514 | LSSPDyVGVTK | PhosphoSitePlus | |
| Y274 | IVTRRyYYSVK | Laminin_N | PhosphoSitePlus |
| S2205 | RKGKVsFLWDV | Laminin_G_1 | PhosphoSitePlus |
| S2567 | IILLGsGGTPA | Laminin_G_1 | PhosphoSitePlus |
| Y1270 | TGFSTyNPQVI | Laminin_B | PhosphoSitePlus |
| Y1249 | KKLMAyGGKLK | HPRD; phosphoELM | |
| Y1258 | LKYAIyFEARE | Laminin_B | PhosphoSitePlus |
| S1358 | RISEIsMEVAE | Laminin_B | PhosphoSitePlus |
| Y1249 | KKLMAyGGKLK | Laminin_B | PhosphoSitePlus |
| S1358 | RISEIsMEVAE | HPRD | |
| Y905 | LCADGyFGDAV | Laminin_EGF | PhosphoSitePlus |
| S2212 | LWDVGsGVGRV | Laminin_G_1 | PhosphoSitePlus |
| S2772 | GLSRNsHIAIA | PhosphoSitePlus | |
| T1369 | QGRGTtMTPPA | HPRD | |
| T2974 | RTTTTtGVLLG | Laminin_G_2 | PhosphoSitePlus |
| Y897 | GTTGRyCELCA | Laminin_EGF | PhosphoSitePlus |
| Y2886 | VVGMLyVGGLP | Laminin_G_1 | PhosphoSitePlus |
| Y1255 | GGKLKyAIYFE | Laminin_B | PhosphoSitePlus |
| Y2894 | GLPINyTTRRI | Laminin_G_1 | PhosphoSitePlus |
| T1369 | QGRGTtMTPPA | Laminin_B | PhosphoSitePlus |
| T2781 | IAFDDtKVKNR | PhosphoSitePlus | |
| Y275 | VTRRYyYSVKD | Laminin_N | PhosphoSitePlus |
| Dephosphorylation site |
| LAMA2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000400365 | E1980V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | R2008T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000400365 | P1160A | BIOMART, HPI | Breast Cancer | 21930507, 21930502, 16959974 | ENSP00000400365 | A2665V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | A1261V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | R369L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | R1366L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | V2529I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | E1738K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000400365 | E1766* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| LAMA2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LAMA2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LAMA2_HUMAN | RSSA_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05146 | Amoebiasis |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| hsa05222 | Small cell lung cancer |
| hsa05145 | Toxoplasmosis |
| hsa05200 | Pathways in cancer |
| hsa05416 | Viral myocarditis |
| hsa04510 | Focal adhesion |
| hsa04512 | ECM-receptor interaction |
| hsa05414 | Dilated cardiomyopathy |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0032224 | positive regulation of synaptic transmission, chol | IEA | biological_process |
| GO:0005604 | basement membrane | IDA | cellular_component |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0005605 | basal lamina | IEA | cellular_component |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0030155 | regulation of cell adhesion | IEA | biological_process |
| GO:0007517 | muscle organ development | TAS | biological_process |
| GO:0045995 | regulation of embryonic development | IEA | biological_process |
| GO:0005198 | structural molecule activity | TAS | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0031012 | extracellular matrix | ISS | cellular_component |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0005606 | laminin-1 complex | IEA | cellular_component |
| GO:0030334 | regulation of cell migration | IEA | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042383 | sarcolemma | IEA | cellular_component |