Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LAMA1_HUMAN
Description:laminin, alpha 1 [Source:HGNC Symbol;Acc:6481]
Location:chr18 p11.23
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1436CDVCTsGYYGKLaminin_EGFPhosphoSitePlus
T2039QELLNtSASLSHPRD
S553GRHQVsINNTAPhosphoSitePlus
S2042LNTSAsLSRVNHPRD
S2040ELLNTsASLSRHPRD
T351KKSLNtAGQFRHPRD; phosphoELM; SysPTM
Y490CKPGFyNLKEKLaminin_EGFPhosphoSitePlus
T581LGNKLtAFGGFLaminin_BPhosphoSitePlus
S31ILNLAsNAHISLaminin_NPhosphoSitePlus
T2187LGSGStRLEFPLaminin_G_1PhosphoSitePlus
T1426NCGDNtAGDHCLaminin_EGFPhosphoSitePlus
Y683AKMALyRLESVLaminin_BPhosphoSitePlus
Y1439CTSGYyGKVTGLaminin_EGFPhosphoSitePlus
S2615GTLVEsRTINVLaminin_G_1PhosphoSitePlus
S348AKQKKsLNTAGLaminin_EGFPhosphoSitePlus
Y337KAKDCyYDESVLaminin_EGFPhosphoSitePlus
T351KKSLNtAGQFRLaminin_EGFPhosphoSitePlus; SysPTM

Dephosphorylation site
LAMA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000374309A2887SCOSMICBreast Cancer17932254
ENSP00000374309N491SCOSMICHead and Neck Cancer21798897
ENSP00000374309R549CCOSMICIntestines Cancer17932254
ENSP00000374309P449SCOSMICSkin Cancer21984974
ENSP00000374309C485YCOSMICPancreatic Cancer
ENSP00000374309Q2224KCOSMICHead and Neck Cancer21798893
ENSP00000374309C1041SCOSMICOvarian Cancer21720365
ENSP00000374309R225CCOSMICSkin Cancer21984974
ENSP00000374309V53GCOSMICBreast Cancer17932254
ENSP00000374309W2285SCOSMICOvarian Cancer21720365
ENSP00000374309S2044FCOSMICMelanoma21499247
ENSP00000374309Q1106HCOSMICHead and Neck Cancer21798893
ENSP00000374309D413NCOSMICIntestines Cancer17932254
ENSP00000374309E1653VBIOMARTBreast Cancer21930507, 21930502
ENSP00000374309A2030VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000374309R1490KCOSMICOvarian Cancer21720365
ENSP00000374309S2337ACOSMICSkin Cancer21984974
ENSP00000374309S1916LCOSMICHead and Neck Cancer21798893
ENSP00000374309D691YCOSMICOvarian Cancer21720365
ENSP00000374309A678GBIOMARTBreast Cancer21930507, 21930502
ENSP00000374309V1300FCOSMICIntestines Cancer17932254
ENSP00000374309R2110HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000374309R2396QCOSMICOvarian Cancer21720365
ENSP00000374309L1314FCOSMICMelanoma21499247
ENSP00000374309L2189VCOSMICHead and Neck Cancer21798897
ENSP00000374309P2543HCOSMICHead and Neck Cancer21798893
ENSP00000374309P1402LCOSMICSkin Cancer21984974
ENSP00000374309G778VCOSMICHead and Neck Cancer21798893
ENSP00000374309E1543*COSMICOvarian Cancer21720365
ENSP00000374309E1038KCOSMICIntestines Cancer17932254
ENSP00000374309K1723TCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000374309Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.1615169874
ENSP00000374309Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
LAMA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LAMA1_HUMANRSSA_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa05146Amoebiasis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa05200Pathways in cancer
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0005201extracellular matrix structural constituentIEAmolecular_function
GO:0005604basement membraneIDAcellular_component
GO:0005606laminin-1 complexIEAcellular_component
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0031175neuron projection developmentIEAbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0007166cell surface receptor signaling pathwayISSbiological_process
GO:0043256laminin complexIEAcellular_component
GO:0005201extracellular matrix structural constituentISSmolecular_function
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0061304retinal blood vessel morphogenesisIEAbiological_process
GO:0005578proteinaceous extracellular matrixISScellular_component
GO:0009888tissue developmentIEAbiological_process
GO:0045198establishment of epithelial cell apical/basal polaIEAbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0031012extracellular matrixTAScellular_component
GO:0043208glycosphingolipid bindingIEAmolecular_function
GO:0005911cell-cell junctionIEAcellular_component
GO:0002011morphogenesis of an epithelial sheetIEAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIEAbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0045995regulation of embryonic developmentIEAbiological_process
GO:0005606laminin-1 complexIPIcellular_component
GO:0005608laminin-3 complexIPIcellular_component
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007411axon guidanceTASbiological_process