Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:L2GL2_HUMAN
Description:lethal giant larvae homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:6629]
Location:chr17 q25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S965NSGTQsDGEEKPhosphoSitePlus; HPRD; phosphoELM
S645LSRVKsLKKSLPhosphoSitePlus
S253CHSDGsYCQWPPhosphoSitePlus
Y499GSFDPySDDPRPhosphoSitePlus
S36FPHQPsALGYSPhosphoSitePlus
S1015VGCSLsNGGHPRD; phosphoELM; SysPTM
T26FQFNKtVEHGFPhosphoSitePlus
Y40PSALGySPSLRPhosphoSitePlus
S961SRARNsGTQSDPhosphoSitePlus
S1015VGCSLsNGGAEPhosphoSitePlus; SysPTM
S802HDLSKsPDMQGLgl_CPhosphoSitePlus
S649KSLKKsLRQSFPhosphoSitePlus
S653KSLRQsFRRMRPhosphoSitePlus

Dephosphorylation site
L2GL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376333A173TBIOMARTBreast Cancer21930507, 21930502
ENSP00000376333E753KCOSMICSkin Cancer21984974
ENSP00000364375A173TBIOMARTBreast Cancer21930507, 21930502
ENSP00000376333Q176*COSMICSkin Cancer21984974
ENSP00000167462A173TBIOMARTBreast Cancer21930507, 21930502
ENSP00000364375A354TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000364375T130RTCGAOvarian Cancer21720365, 18772890
ENSP00000376333T130RCOSMICOvarian Cancer21720365
ENSP00000376333A525TCOSMICSkin Cancer21984974

Differential expressed protein
L2GL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
L2GL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCI_HUMANL2GL2_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006887exocytosisIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0030165PDZ domain bindingIPImolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0032878regulation of establishment or maintenance of cellIDAbiological_process


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