| UniProt/SwissProt ID: | L2GL2_HUMAN |
| Description: | lethal giant larvae homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:6629] |
| Location: | chr17 q25.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S965 | NSGTQsDGEEK | PhosphoSitePlus; HPRD; phosphoELM | |
| S645 | LSRVKsLKKSL | PhosphoSitePlus | |
| S253 | CHSDGsYCQWP | PhosphoSitePlus | |
| Y499 | GSFDPySDDPR | PhosphoSitePlus | |
| S36 | FPHQPsALGYS | PhosphoSitePlus | |
| S1015 | VGCSLsNGG | HPRD; phosphoELM; SysPTM | |
| T26 | FQFNKtVEHGF | PhosphoSitePlus | |
| Y40 | PSALGySPSLR | PhosphoSitePlus | |
| S961 | SRARNsGTQSD | PhosphoSitePlus | |
| S1015 | VGCSLsNGGAE | PhosphoSitePlus; SysPTM | |
| S802 | HDLSKsPDMQG | Lgl_C | PhosphoSitePlus |
| S649 | KSLKKsLRQSF | PhosphoSitePlus | |
| S653 | KSLRQsFRRMR | PhosphoSitePlus | |
| Dephosphorylation site |
| L2GL2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376333 | A173T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376333 | E753K | COSMIC | Skin Cancer | 21984974 | ENSP00000364375 | A173T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000376333 | Q176* | COSMIC | Skin Cancer | 21984974 | ENSP00000167462 | A173T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000364375 | A354T | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000364375 | T130R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000376333 | T130R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000376333 | A525T | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| L2GL2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| L2GL2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCI_HUMAN | L2GL2_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006887 | exocytosis | IEA | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0032878 | regulation of establishment or maintenance of cell | IDA | biological_process |