Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPB1_HUMAN
Description:phosphorylase kinase, alpha 1 (muscle) [Source:HGNC Symbol;Acc:8925]
Location:chrX q13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y717QNVHMyLPTKLGlyco_hydro_15PhosphoSitePlus
S972FGVERsVRPTDphosphoELM
S405HMWGQsLYILGGlyco_hydro_15PhosphoSitePlus
S1036TPSSGsFPSAYGlyco_hydro_15PhosphoSitePlus
S758LPRDQsGEVDFGlyco_hydro_15PhosphoSitePlus
S972FGVERsVRPTDPHK_groupphosphoELM; RegPhos
S981TDSNVsPAISIHPRD; phosphoELM
S5_MRSRsNSGVRGlyco_hydro_15PhosphoSitePlus
S972FGVERsVRPTDPHKA1HPRD
S985VSPAIsIHEIGPHKA1HPRD
S1018EFRRLsISAESGlyco_hydro_15PhosphoSitePlus
S1020RRLSIsAESQSGlyco_hydro_15PhosphoSitePlus
S972FGVERsVRPTDP46020(Phosphorylase kinaRegPhos
S978VRPTDsNVSPAHPRD; phosphoELM
S1007IMQLKsEIKQVP46020(Phosphorylase kinaRegPhos
S1018EFRRLsISAESPRKACAHPRD
S735FNLLDsPHPRQGlyco_hydro_15PhosphoSitePlus; SysPTM
S1007IMQLKsEIKQVautocatalysis RegPhos
S981TDSNVsPAISIGlyco_hydro_15PhosphoSitePlus
S735FNLLDsPHPRQHPRD; SysPTM
T561MTGQPtITFPIHPRD; phosphoELM
Y407WGQSLyILGSLGlyco_hydro_15PhosphoSitePlus
S1018EFRRLsISAESPKA_group RegPhos
S972FGVERsVRPTDautocatalysis RegPhos
S985VSPAIsIHEIGPHK_groupphosphoELM; RegPhos
T432NRRFStVPKPDGlyco_hydro_15PhosphoSitePlus
T453TEEIKtILKDKGlyco_hydro_15PhosphoSitePlus
S1018EFRRLsISAESPKACaRegPhos
S1007IMQLKsEIKQVPHKA1HPRD
T976RSVRPtDSNVSGlyco_hydro_15PhosphoSitePlus
S1007IMQLKsEIKQVPHK_groupphosphoELM; RegPhos
S1018EFRRLsISAESPHKA1HPRD
S985VSPAIsIHEIGphosphoELM
T563GQPTItFPISHHPRD; phosphoELM
T943SAEEAtEGLMNGlyco_hydro_15PhosphoSitePlus
Y636DYDDNyDYLESGlyco_hydro_15PhosphoSitePlus
Y312DPNRLyYEPAEGlyco_hydro_15PhosphoSitePlus
S729QASRPsFNLLDGlyco_hydro_15PhosphoSitePlus
S985VSPAIsIHEIGP46020(Phosphorylase kinaRegPhos
S985VSPAIsIHEIGGlyco_hydro_15PhosphoSitePlus
S1034SMTPSsGSFPSGlyco_hydro_15PhosphoSitePlus
S985VSPAIsIHEIGautocatalysis RegPhos
Y549RTDLSyLCSRWGlyco_hydro_15PhosphoSitePlus
S1018EFRRLsISAESPHK_groupphosphoELM; RegPhos
S1033TSMTPsSGSFPGlyco_hydro_15PhosphoSitePlus
S972FGVERsVRPTDGlyco_hydro_15PhosphoSitePlus
Y638DDNYDyLESGNGlyco_hydro_15PhosphoSitePlus
Y469TIAEVyPIRVQGlyco_hydro_15PhosphoSitePlus
S1023SISAEsQSPGTHPRD; RegPhos
S431LNRRFsTVPKPGlyco_hydro_15PhosphoSitePlus
S726KLFQAsRPSFNGlyco_hydro_15PhosphoSitePlus
S7RSRSNsGVRLDGlyco_hydro_15PhosphoSitePlus
S1018EFRRLsISAESP46020(Phosphorylase kinaRegPhos
S934TELAHsLRCSAGlyco_hydro_15PhosphoSitePlus
S581TSLNSsILAALHPRD; phosphoELM
S1020RRLSIsAESQSHPRD; phosphoELM; RegPhos
Y632LYSEDyDDNYDGlyco_hydro_15PhosphoSitePlus

Dephosphorylation site
KPB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362643R491TCOSMICOvarian Cancer21720365
ENSP00000362643Y628CCOSMICHead and Neck Cancer21798893
ENSP00000362643A466SCOSMICOvarian Cancer21720365
ENSP00000362643R807KCOSMICHepatocellular Carcinoma21822264
ENSP00000362643R802WCOSMICOvarian Cancer21720365
ENSP00000362643W130GCOSMICMelanoma21499247

Differential expressed protein
KPB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPB1_HUMANKPB1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKPB1_HUMANkinase -> substrateRegPhos
KPCA_HUMANKPB1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005980glycogen catabolic processTASbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005977glycogen metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0004689phosphorylase kinase activityTASmolecular_function
GO:0006006glucose metabolic processTASbiological_process
GO:0006091generation of precursor metabolites and energyTASbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005976polysaccharide metabolic processIEAbiological_process


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