Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KNG1_HUMAN
Description:kininogen 1 [Source:HGNC Symbol;Acc:6383]
Location:chr3 q27.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S329RETTCsKESNECystatinPhosphoSitePlus
T327VARETtCSKESHPRD
T171YFNNNtQHSSLCystatinPhosphoSitePlus
T110GECTAtVGKRSCystatinPhosphoSitePlus
T326FVAREtTCSKEHPRD
S332TCSKEsNEELTCystatinPhosphoSitePlus
S390FSPFRsSRIGEBradykininPhosphoSitePlus
S332TCSKEsNEELTHPRD
T327VARETtCSKESCystatinPhosphoSitePlus
S391SPFRSsRIGEIPhosphoSitePlus
S175NTQHSsLFMLNCystatinPhosphoSitePlus
T326FVAREtTCSKECystatinPhosphoSitePlus
T342TESCEtKKLGQCystatinPhosphoSitePlus
S329RETTCsKESNEHPRD
S174NNTQHsSLFMLCystatinPhosphoSitePlus

Dephosphorylation site
KNG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265023L441IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000287611E423DCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265023Pancreatic CancerNormal vs. CancertissueUp1.916212428
ENSP00000265023Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp219422301
ENSP00000265023Ovarian CancerNormal vs. CancertissueUp2.220162585

Hyperphosphorylation site
KNG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KNG1_HUMANBKRB2_HUMANligand -> receptorHPMR
KNG1_HUMANBKRB1_HUMANligand -> receptorHPMR
KNG1_HUMANGP135_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007162negative regulation of cell adhesionIDAbiological_process
GO:0035810positive regulation of urine volumeTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0008270zinc ion bindingNASmolecular_function
GO:0043065positive regulation of apoptotic processNASbiological_process
GO:0042311vasodilationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007597blood coagulation, intrinsic pathwayTASbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0035815positive regulation of renal sodium excretionTASbiological_process
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0004869cysteine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0006939smooth muscle contractionTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0030195negative regulation of blood coagulationIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005576extracellular regionNAScellular_component
GO:0008201heparin bindingNASmolecular_function


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