| UniProt/SwissProt ID: | KLK3_HUMAN |
| Description: | kallikrein-related peptidase 3 [Source:HGNC Symbol;Acc:6364] |
| Location: | chr19 q13.33 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T167 | PEEFLtPKKLQ | HPRD | |
| T124 | PEEFLtPKKLQ | HPRD | |
| T143 | VMDLPtQEPAL | Trypsin | PhosphoSitePlus |
| T100 | VMDLPtQEPAL | HPRD | |
| T167 | PEEFLtPKKLQ | Trypsin | PhosphoSitePlus |
| T143 | VMDLPtQEPAL | HPRD | |
| Dephosphorylation site |
| KLK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000314151 | R45H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314151 | H78Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000314151 | A235V | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000314151 | E238K | COSMIC | Renal Cancer | 20054297 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000314151 | Prostate Cancer | Treatment (androgen-starved vs. androgen-stimulated) | cell line | Up | 3.5 | 14729644 |
| Hyperphosphorylation site |
| KLK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANDR_HUMAN | KLK3_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KLK3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0008236 | serine-type peptidase activity | TAS | molecular_function |
| GO:0016525 | negative regulation of angiogenesis | NAS | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0004252 | serine-type endopeptidase activity | IEA | molecular_function |