| UniProt/SwissProt ID: | KITH_HUMAN |
| Description: | thymidine kinase 1, soluble [Source:HGNC Symbol;Acc:11830] |
| Location: | chr17 q25.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S13 | TVLPGsPSKTR | PhosphoSitePlus; RegPhos | |
| Y181 | GGADKyHSVCR | TK | PhosphoSitePlus |
| S183 | ADKYHsVCRLC | TK | PhosphoSitePlus |
| S13 | TVLPGsPSKTR | CDC2(CDK1 | RegPhos |
| S15 | LPGSPsKTRGQ | HPRD | |
| Y48 | FQIAQyKCLVI | TK | PhosphoSitePlus |
| Y55 | CLVIKyAKDTR | TK | PhosphoSitePlus |
| S13 | TVLPGsPSKTR | CDC2 | RegPhos |
| S231 | QILQCsP | HPRD; phosphoELM; SysPTM | |
| S13 | TVLPGsPSKTR | CDK2 | phosphoELM; RegPhos |
| S231 | QILQCsPAN | RegPhos; SysPTM | |
| S231 | QILQCsPAN__ | PhosphoSitePlus; SysPTM | |
| S13 | TVLPGsPSKTR | CDK1 | HPRD; phosphoELM |
| Dephosphorylation site |
| KITH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| KITH_HUMAN do not have mutation site. |
| Differential expressed protein |
| KITH_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KITH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | KITH_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | KITH_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | KITH_HUMAN | kinase -> substrate | RegPhos |
| SP1_HUMAN | KITH_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa00983 | Drug metabolism - other enzymes |
| hsa00240 | Pyrimidine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0060138 | fetal process involved in parturition | IEA | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0043097 | pyrimidine nucleoside salvage | TAS | biological_process |
| GO:0051414 | response to cortisol stimulus | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004797 | thymidine kinase activity | IEA | molecular_function |
| GO:0006139 | nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0051289 | protein homotetramerization | IPI | biological_process |
| GO:0006206 | pyrimidine nucleobase metabolic process | TAS | biological_process |
| GO:0055086 | nucleobase-containing small molecule metabolic pro | TAS | biological_process |
| GO:0048565 | digestive tract development | IEA | biological_process |
| GO:0009636 | response to toxin | IEA | biological_process |
| GO:0046688 | response to copper ion | IEA | biological_process |
| GO:0019206 | nucleoside kinase activity | EXP | molecular_function |
| GO:0001889 | liver development | IEA | biological_process |
| GO:0014856 | skeletal muscle cell proliferation | IEA | biological_process |
| GO:0008270 | zinc ion binding | IDA | molecular_function |
| GO:0031667 | response to nutrient levels | IEA | biological_process |
| GO:0009165 | nucleotide biosynthetic process | EXP | biological_process |
| GO:0046104 | thymidine metabolic process | IEA | biological_process |