| UniProt/SwissProt ID: | KIF2C_HUMAN |
| Description: | kinesin family member 2C [Source:HGNC Symbol;Acc:6393] |
| Location: | chr1 p34.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T537 | QNKAHtPFRES | Kinesin; UvrD_C | PhosphoSitePlus |
| S95 | KQKRRsVNSKI | PhosphoSitePlus; phosphoELM | |
| S611 | EMEACsNGALI | UvrD_C | PhosphoSitePlus |
| S632 | LSSQMsSFNEA | HPRD; phosphoELM; RegPhos | |
| T150 | VPPAPtRPSCP | PhosphoSitePlus | |
| S179 | HSIRGsSSANP | HPRD | |
| S187 | ANPVNsVRRKS | PhosphoSitePlus | |
| S192 | SVRRKsCLVKE | PhosphoSitePlus | |
| S629 | EEELSsQMSSF | HPRD; phosphoELM; RegPhos | |
| T461 | RTSGQtFANSN | Kinesin | PhosphoSitePlus |
| S95 | KQKRRsVNSKI | AurB(Aurora B | RegPhos |
| S95 | KQKRRsVNSKI | Aurora B | phosphoELM |
| S111 | SLRSRsTRMST | PhosphoSitePlus; HPRD | |
| S489 | MHGKFsLVDLA | Kinesin | PhosphoSitePlus |
| S633 | SSQMSsFNEAM | HPRD; phosphoELM; RegPhos | |
| T116 | STRMStVSELR | PhosphoSitePlus; HPRD | |
| S628 | EEEELsSQMSS | HPRD; phosphoELM; RegPhos | |
| S621 | IPGNLsKEEEE | UvrD_C | PhosphoSitePlus |
| Y398 | LGLEVyVTFFE | Kinesin | PhosphoSitePlus |
| S106 | PAPKEsLRSRS | PhosphoSitePlus; HPRD; phosphoELM | |
| S621 | IPGNLsKEEEE | HPRD | |
| S109 | KESLRsRSTRM | PhosphoSitePlus | |
| S22 | IKIQRsNGLIH | PhosphoSitePlus; HPRD | |
| S633 | SSQMSsFNEAM | UvrD_C | PhosphoSitePlus |
| S144 | SRKQFsVPPAP | PhosphoSitePlus | |
| S719 | ASRQIsSKKRP | UvrD_C | PhosphoSitePlus |
| Y223 | KRAQEyDSSFP | PhosphoSitePlus | |
| S166 | PLRMVsEEMEE | PhosphoSitePlus; HPRD; phosphoELM | |
| S115 | RSTRMsTVSEL | PhosphoSitePlus; HPRD | |
| S519 | AEINKsLLALK | Kinesin; UvrD_C | PhosphoSitePlus |
| S629 | EEELSsQMSSF | UvrD_C | PhosphoSitePlus |
| S175 | EEQVHsIRGSS | PhosphoSitePlus | |
| S519 | AEINKsLLALK | HPRD | |
| T604 | LIQMEtEEMEA | HPRD | |
| S611 | EMEACsNGALI | phosphoELM | |
| Y374 | ASKGIyAMASR | Kinesin | PhosphoSitePlus |
| T112 | LRSRStRMSTV | PhosphoSitePlus | |
| Y405 | TFFEIyNGKLF | Kinesin | PhosphoSitePlus |
| S632 | LSSQMsSFNEA | UvrD_C | PhosphoSitePlus |
| Dephosphorylation site |
| KIF2C_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361298 | E207K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000361298 | I56M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361291 | E153K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361298 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| KIF2C_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | KIF2C_HUMAN | kinase -> substrate | RegPhos |
| AURKB_HUMAN | KIF2C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KIF2C_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007019 | microtubule depolymerization | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005871 | kinesin complex | TAS | cellular_component |
| GO:0019237 | centromeric DNA binding | TAS | molecular_function |
| GO:0007059 | chromosome segregation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0007018 | microtubule-based movement | IEA | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0003777 | microtubule motor activity | IEA | molecular_function |
| GO:0019886 | antigen processing and presentation of exogenous p | TAS | biological_process |
| GO:0000776 | kinetochore | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005881 | cytoplasmic microtubule | ISS | cellular_component |
| GO:0051983 | regulation of chromosome segregation | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000775 | chromosome, centromeric region | IEA | cellular_component |
| GO:0030951 | establishment or maintenance of microtubule cytosk | IMP | biological_process |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0007067 | mitosis | TAS | biological_process |
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0005875 | microtubule associated complex | IEA | cellular_component |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0000777 | condensed chromosome kinetochore | IEA | cellular_component |
| GO:0051010 | microtubule plus-end binding | IDA | molecular_function |