Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KIF2C_HUMAN
Description:kinesin family member 2C [Source:HGNC Symbol;Acc:6393]
Location:chr1 p34.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T537QNKAHtPFRESKinesin; UvrD_CPhosphoSitePlus
S95KQKRRsVNSKIPhosphoSitePlus; phosphoELM
S611EMEACsNGALIUvrD_CPhosphoSitePlus
S632LSSQMsSFNEAHPRD; phosphoELM; RegPhos
T150VPPAPtRPSCPPhosphoSitePlus
S179HSIRGsSSANPHPRD
S187ANPVNsVRRKSPhosphoSitePlus
S192SVRRKsCLVKEPhosphoSitePlus
S629EEELSsQMSSFHPRD; phosphoELM; RegPhos
T461RTSGQtFANSNKinesinPhosphoSitePlus
S95KQKRRsVNSKIAurB(Aurora BRegPhos
S95KQKRRsVNSKIAurora BphosphoELM
S111SLRSRsTRMSTPhosphoSitePlus; HPRD
S489MHGKFsLVDLAKinesinPhosphoSitePlus
S633SSQMSsFNEAMHPRD; phosphoELM; RegPhos
T116STRMStVSELRPhosphoSitePlus; HPRD
S628EEEELsSQMSSHPRD; phosphoELM; RegPhos
S621IPGNLsKEEEEUvrD_CPhosphoSitePlus
Y398LGLEVyVTFFEKinesinPhosphoSitePlus
S106PAPKEsLRSRSPhosphoSitePlus; HPRD; phosphoELM
S621IPGNLsKEEEEHPRD
S109KESLRsRSTRMPhosphoSitePlus
S22IKIQRsNGLIHPhosphoSitePlus; HPRD
S633SSQMSsFNEAMUvrD_CPhosphoSitePlus
S144SRKQFsVPPAPPhosphoSitePlus
S719ASRQIsSKKRPUvrD_CPhosphoSitePlus
Y223KRAQEyDSSFPPhosphoSitePlus
S166PLRMVsEEMEEPhosphoSitePlus; HPRD; phosphoELM
S115RSTRMsTVSELPhosphoSitePlus; HPRD
S519AEINKsLLALKKinesin; UvrD_CPhosphoSitePlus
S629EEELSsQMSSFUvrD_CPhosphoSitePlus
S175EEQVHsIRGSSPhosphoSitePlus
S519AEINKsLLALKHPRD
T604LIQMEtEEMEAHPRD
S611EMEACsNGALIphosphoELM
Y374ASKGIyAMASRKinesinPhosphoSitePlus
T112LRSRStRMSTVPhosphoSitePlus
Y405TFFEIyNGKLFKinesinPhosphoSitePlus
S632LSSQMsSFNEAUvrD_CPhosphoSitePlus

Dephosphorylation site
KIF2C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361298E207KBIOMARTBreast Cancer21930507, 21930502
ENSP00000361298I56MCOSMICOvarian Cancer21720365
ENSP00000361291E153KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361298Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
KIF2C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANKIF2C_HUMANkinase -> substrateRegPhos
AURKB_HUMANKIF2C_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KIF2C_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007019microtubule depolymerizationIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0005871kinesin complexTAScellular_component
GO:0019237centromeric DNA bindingTASmolecular_function
GO:0007059chromosome segregationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0007018microtubule-based movementIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0003777microtubule motor activityIEAmolecular_function
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005881cytoplasmic microtubuleISScellular_component
GO:0051983regulation of chromosome segregationIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0030951establishment or maintenance of microtubule cytoskIMPbiological_process
GO:0000236mitotic prometaphaseTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007067mitosisTASbiological_process
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0005875microtubule associated complexIEAcellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0051010microtubule plus-end bindingIDAmolecular_function


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