| UniProt/SwissProt ID: | KIBRA_HUMAN |
| Description: | WW and C2 domain containing 1 [Source:HGNC Symbol;Acc:29435] |
| Location: | chr5 q34 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y788 | LLSYKyLKKQS | PhosphoSitePlus | |
| Y128 | LAQQEyQQLHA | PhosphoSitePlus | |
| Y781 | RSTRWyNLLSY | PhosphoSitePlus | |
| S975 | MKRPSsVKSLR | PhosphoSitePlus | |
| S815 | STDAVsALLEQ | PhosphoSitePlus | |
| S255 | RTDRGsHSDLW | PhosphoSitePlus | |
| T527 | RSLSGtPKSMT | PhosphoSitePlus | |
| S539 | LSPRSsLSSPS | PhosphoSitePlus | |
| T895 | ETNTEtPAPSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S975 | MKRPSsVKSLR | PRKCZ | HPRD |
| S931 | RSKTFsPGPQS | PhosphoSitePlus; HPRD; phosphoELM | |
| T901 | PAPSPtVVRPK | PhosphoSitePlus | |
| S427 | QLKSLsSSMQS | PhosphoSitePlus | |
| S542 | RSSLSsPSPPC | PhosphoSitePlus | |
| S927 | STIIRsKTFSP | HPRD | |
| S978 | PSSVKsLRSER | PhosphoSitePlus | |
| T923 | FLRGStIIRSK | HPRD | |
| Y938 | GPQSQyVCRLN | PhosphoSitePlus | |
| S241 | QDLIKsLAMLK | PhosphoSitePlus | |
| S978 | PSSVKsLRSER | PRKCZ | HPRD |
| S523 | LQALRsLSGTP | PhosphoSitePlus | |
| S947 | LNRSDsDSSTL | PhosphoSitePlus; HPRD; phosphoELM | |
| T929 | IIRSKtFSPGP | PhosphoSitePlus; HPRD; phosphoELM | |
| S899 | ETPAPsPTVVR | PhosphoSitePlus; HPRD; phosphoELM | |
| S922 | PFLRGsTIIRS | HPRD | |
| T912 | DRRVGtPSQGP | PhosphoSitePlus; HPRD; phosphoELM | |
| S945 | CRLNRsDSDSS | PhosphoSitePlus | |
| Y786 | YNLLSyKYLKK | PhosphoSitePlus | |
| T893 | DKETNtETPAP | PhosphoSitePlus | |
| Dephosphorylation site |
| KIBRA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000427772 | R989H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265293 | R983H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265293 | Q104* | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| KIBRA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KIBRA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | KIBRA_HUMAN | kinase -> substrate | RegPhos |
| KPCZ_HUMAN | KIBRA_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KIBRA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0035330 | regulation of hippo signaling cascade | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016477 | cell migration | IDA | biological_process |
| GO:0032587 | ruffle membrane | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016477 | cell migration | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0043410 | positive regulation of MAPK cascade | IDA | biological_process |
| GO:0003713 | transcription coactivator activity | IDA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0030674 | protein binding, bridging | IEA | molecular_function |
| GO:0035329 | hippo signaling cascade | TAS | biological_process |