| UniProt/SwissProt ID: | KI3L2_HUMAN |
| Description: | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 [Source:HGNC Symbol;Acc:6339] |
| Location: | chrHSCHR19LRC_PGF1_C |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S66 | YKEDRsHVPIF | ig | PhosphoSitePlus |
| Y428 | TDTSVyTELPN | PhosphoSitePlus | |
| Y398 | PQEVTyAQLDH | PhosphoSitePlus | |
| Dephosphorylation site |
| KI3L2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000325525 | R96Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000325525 | Y398N | COSMIC | Skin Cancer | 21984974 | ENSP00000325525 | N384D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| KI3L2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KI3L2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| 1A80_HUMAN | KI3L2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04612 | Antigen processing and presentation |
| hsa05332 | Graft-versus-host disease |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006968 | cellular defense response | TAS | biological_process |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |