| UniProt/SwissProt ID: | KI2L4_HUMAN |
| Description: | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 [Source:HGNC Symbol;Acc:6332] |
| Location: | chr19 q13.42 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S356 | ALMGSsRETTA | PhosphoSitePlus | |
| Y74 | PVPELyNRIFW | PhosphoSitePlus | |
| Y123 | MVTGLyEKPSL | PhosphoSitePlus | |
| S355 | QALMGsSRETT | PhosphoSitePlus | |
| Dephosphorylation site |
| KI2L4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339634 | L13H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000350088 | P126L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339634 | P126L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000379588 | P31L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350088 | R54S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339634 | R54S | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| KI2L4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KI2L4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HLAG_HUMAN | KI2L4_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04612 | Antigen processing and presentation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006968 | cellular defense response | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0050776 | regulation of immune response | TAS | biological_process |