| UniProt/SwissProt ID: | KI2L1_HUMAN |
| Description: | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 [Source:HGNC Symbol;Acc:6329] |
| Location: | chr19 q13.42 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T311 | NHCVFtQRKIT | PhosphoSitePlus | |
| Y302 | PQEVTyTQLNH | PhosphoSitePlus | |
| Y332 | TDIIVyTELPN | PhosphoSitePlus | |
| T180 | PKVNGtFQADF | ig | PhosphoSitePlus |
| S281 | VMDQEsAGNRT | PhosphoSitePlus | |
| Dephosphorylation site |
| KI2L1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000336769 | R99I | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000336769 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Up | 1.6 | 15169874 |
| Hyperphosphorylation site |
| KI2L1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| 1C18_HUMAN | KI2L1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa05332 | Graft-versus-host disease |
| hsa04612 | Antigen processing and presentation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0002769 | natural killer cell inhibitory signaling pathway | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |