| UniProt/SwissProt ID: | KCNQ2_HUMAN |
| Description: | potassium voltage-gated channel, KQT-like subfamily, member 2 [Source:HGNC Symbol;Acc:6296] |
| Location: | chr20 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S551 | MRFLVsKRKFK | PRKCA | HPRD |
| S229 | VVYAHsKELVT | Ion_trans | PhosphoSitePlus |
| S551 | MRFLVsKRKFK | PKCa | RegPhos |
| Y379 | SQTQTyGASRL | PhosphoSitePlus | |
| Y372 | VTVPMySSQTQ | PhosphoSitePlus | |
| S445 | KDRVFsSPRGV | PhosphoSitePlus | |
| S843 | ESDTDsDLCTP | KCNQC3-Ank-G_bd | PhosphoSitePlus |
| S468 | VRRSPsADQSL | RegPhos | |
| S533 | MRFLVsKRKFK | PRKCA | HPRD |
| T857 | PPRSAtGEGPF | KCNQC3-Ank-G_bd | PhosphoSitePlus |
| T217 | DRRGGtWKLLG | TM; Ion_trans | PhosphoSitePlus |
| Y658 | TETEAyFGAKE | KCNQ_channel | PhosphoSitePlus |
| Y571 | DVIEQySAGHL | KCNQ_channel | PhosphoSitePlus |
| S52 | APKRGsILSKP | PhosphoSitePlus | |
| S558 | RKFKEsLRPYD | PRKCA | HPRD |
| Y644 | FLVNIyMQRMG | KCNQ_channel | PhosphoSitePlus |
| S520 | MRFLVsKRKFK | PRKCA | HPRD |
| S855 | GPPPRsATGEG | KCNQC3-Ank-G_bd | PhosphoSitePlus |
| S530 | RKFKEsLRPYD | PRKCA | HPRD |
| S52 | APKRGsILSKP | PKA_group | RegPhos |
| Y237 | LVTAWyIGFLC | TM; Ion_trans | PhosphoSitePlus |
| Y562 | ESLRPyDVMDV | KCNQ_channel | PhosphoSitePlus |
| S438 | SSQKVsLKDRV | PhosphoSitePlus | |
| S523 | MRFLVsKRKFK | PRKCA | HPRD |
| Y74 | KRNAFyRKLQN | DUF2189 | PhosphoSitePlus |
| S558 | RKFKEsLRPYD | PKCa | RegPhos |
| S527 | RKFKEsLRPYD | PRKCA | HPRD |
| S540 | RKFKEsLRPYD | PRKCA | HPRD |
| S466 | QTVRRsPSADQ | RegPhos | |
| Dephosphorylation site |
| KCNQ2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000352035 | A667T | COSMIC | Skin Cancer | 21984974 | ENSP00000352035 | S122L | COSMIC | Skin Cancer | 21984974 | ENSP00000352035 | E231A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352035 | T274M | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000352035 | G279S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| KCNQ2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KCNQ2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | KCNQ2_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | KCNQ2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04725 | Cholinergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0055085 | transmembrane transport | IEA | biological_process |
| GO:0043194 | axon initial segment | ISS | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005267 | potassium channel activity | TAS | molecular_function |
| GO:0008076 | voltage-gated potassium channel complex | IEA | cellular_component |
| GO:0033268 | node of Ranvier | ISS | cellular_component |
| GO:0005251 | delayed rectifier potassium channel activity | IBA | molecular_function |
| GO:0005216 | ion channel activity | IEA | molecular_function |
| GO:0030506 | ankyrin binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | ISS | cellular_component |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0019226 | transmission of nerve impulse | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006811 | ion transport | IEA | biological_process |
| GO:0006813 | potassium ion transport | TAS | biological_process |
| GO:0005249 | voltage-gated potassium channel activity | TAS | molecular_function |