Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KCNC4_HUMAN
Description:potassium voltage-gated channel, Shaw-related subfamily, member 4 [Source:HGNC Symbol;Acc:6236]
Location:chr1 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S15YRGRKsGNKPPPKC_gammaphosphoELM
S21GNKPPsKTCLKRegPhos
S8SSVCVsSYRGRPKC_gammaphosphoELM
S21GNKPPsKTCLKPKCb(PKC betaRegPhos
S9SVCVSsYRGRKRegPhos
S8SSVCVsSYRGRPKCa(PKC alphaRegPhos
S8SSVCVsSYRGRPKCb(PKC betaRegPhos
S9SVCVSsYRGRKPKC_alphaphosphoELM
S8SSVCVsSYRGRRegPhos
S8SSVCVsSYRGRPKCg(PKC gammaRegPhos
S8SSVCVsSYRGRPKC_betaphosphoELM
S8SSVCVsSYRGRPKC_alphaphosphoELM
S8SSVCVsSYRGRPotassium_channPhosphoSitePlus
S21GNKPPsKTCLKPKC_alphaphosphoELM
S15YRGRKsGNKPPPKC_betaphosphoELM
S9SVCVSsYRGRKPKCa(PKC alphaRegPhos
Y597LSTGDyACADGPhosphoSitePlus
S9SVCVSsYRGRKPKCg(PKC gammaRegPhos
S21GNKPPsKTCLKPKCa(PKC alphaRegPhos
S9SVCVSsYRGRKPKCb(PKC betaRegPhos
Y50TRHETyRSTLRK_tetraPhosphoSitePlus
S15YRGRKsGNKPPPKCa(PKC alphaRegPhos
S15YRGRKsGNKPPRegPhos
S15YRGRKsGNKPPPKC_alphaphosphoELM
S9SVCVSsYRGRKPKC_betaphosphoELM
S15YRGRKsGNKPPPKCg(PKC gammaRegPhos
S21GNKPPsKTCLKPKC_gammaphosphoELM
S15YRGRKsGNKPPPotassium_channPhosphoSitePlus
S9SVCVSsYRGRKPotassium_channPhosphoSitePlus
S21GNKPPsKTCLKPKC_betaphosphoELM
S21GNKPPsKTCLKPKCg(PKC gammaRegPhos
T49GTRHEtYRSTLK_tetraPhosphoSitePlus
S9SVCVSsYRGRKPKC_gammaphosphoELM
S15YRGRKsGNKPPPKCb(PKC betaRegPhos
S21GNKPPsKTCLKPotassium_channPhosphoSitePlus

Dephosphorylation site
KCNC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358802E28-Sjoblom2006Intestines Cancer16959974
ENSP00000358802F235LCOSMICOvarian Cancer21720365
ENSP00000358802E28delBIOMARTColorectal Cancer21930507, 21930502
ENSP00000393655F235LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358802LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineUp17449014

Hyperphosphorylation site
KCNC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANKCNC4_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKCNC4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KCNC4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0043679axon terminusIEAcellular_component
GO:0008076voltage-gated potassium channel complexIEAcellular_component
GO:0005216ion channel activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0055085transmembrane transportIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006811ion transportIEAbiological_process
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0005267potassium channel activityTASmolecular_function
GO:0031594neuromuscular junctionIEAcellular_component
GO:0005249voltage-gated potassium channel activityTASmolecular_function
GO:0005251delayed rectifier potassium channel activityIBAmolecular_function
GO:0006813potassium ion transportTASbiological_process
GO:0007268synaptic transmissionTASbiological_process


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