Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KAP2_HUMAN
Description:protein kinase, cAMP-dependent, regulatory, type II, alpha [Source:HGNC Symbol;Acc:9391]
Location:chr3 p21.31
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y352RAASAyAVGDVHPRD
S196DNQTRsVGQYDcNMP_bindingPhosphoSitePlus
S99FNRRVsVCAETPRKAR2AHPRD
S350KPRAAsAYAVGHPRD
S99FNRRVsVCAETPKA_groupphosphoELM
S254RKMFEsFIESVPhosphoSitePlus
Y105VCAETyNPDEEPhosphoSitePlus; HPRD
S58ATPRQsLGHPPPhosphoSitePlus; HPRD; phosphoELM
T343ELALVtNKPRAcNMP_bindingPhosphoSitePlus
Y385RNISHyEEQLVPhosphoSitePlus
S350KPRAAsAYAVGcNMP_bindingPhosphoSitePlus
Y352RAASAyAVGDVcNMP_bindingPhosphoSitePlus
S92EVPVPsRFNRRPhosphoSitePlus
T104SVCAEtYNPDEPhosphoSitePlus; HPRD
T290GERIItQGEKAcNMP_bindingPhosphoSitePlus
S78DAKGDsESEEDPhosphoSitePlus; HPRD; phosphoELM
S48ARAPAsVLPAAPhosphoSitePlus; HPRD
S80KGDSEsEEDEDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S99FNRRVsVCAETPhosphoSitePlus
Y200RSVGQyDNRGScNMP_bindingPhosphoSitePlus
T54VLPAAtPRQSLPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
KAP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265563K358NCOSMICOvarian Cancer21720365
ENSP00000394041K358NCOSMICOvarian Cancer21720365

Differential expressed protein
KAP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KAP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KAP2_HUMANKAP2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0030552cAMP bindingIEAmolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005952cAMP-dependent protein kinase complexIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0008603cAMP-dependent protein kinase regulator activityNASmolecular_function
GO:0050796regulation of insulin secretionTASbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0016020membraneTAScellular_component
GO:0006833water transportTASbiological_process