Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITF2_HUMAN
Description:transcription factor 4 [Source:HGNC Symbol;Acc:11634]
Location:chr18 q21.2
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S56EDRSSsGSWGNCK2_alphaphosphoELM
S54NVEDRsSSGSWCK2a1(CK2 alphaRegPhos
Y149PGSQYyQYSSNPhosphoSitePlus
S55VEDRSsSGSWGCK2_alphaphosphoELM
S372GQASSsPNYEGPhosphoSitePlus; phosphoELM
S54NVEDRsSSGSWPhosphoSitePlus
S56EDRSSsGSWGNCK2a1(CK2 alphaRegPhos
S68GHPSPsRNYGDPhosphoSitePlus
S515SSEIKsDDEGDPhosphoSitePlus
S55VEDRSsSGSWGPhosphoSitePlus
T554DDEDLtPEQKAPhosphoSitePlus
S54NVEDRsSSGSWCK2_alphaphosphoELM
S481QLPVQsATSPDHPRD
S56EDRSSsGSWGNPhosphoSitePlus
S55VEDRSsSGSWGCK2a1(CK2 alphaRegPhos
S318GAAGSsQTGDAPhosphoSitePlus

Dephosphorylation site
ITF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348374L607FCOSMICSkin Cancer21984974
ENSP00000348374G658*COSMICOvarian Cancer21720365
ENSP00000348374I606FCOSMICLung Cancer20668451
ENSP00000457649I606FCOSMICLung Cancer20668451
ENSP00000457649L607FCOSMICSkin Cancer21984974
ENSP00000457649G658*COSMICOvarian Cancer21720365

Differential expressed protein
ITF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ITF2_HUMANAMHR2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ITF2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0001093TFIIB-class transcription factor bindingIEAmolecular_function
GO:0070888E-box bindingISSmolecular_function
GO:0006352DNA-dependent transcription, initiationISSbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0006367transcription initiation from RNA polymerase II prIEAbiological_process
GO:0001093TFIIB-class transcription factor bindingISSmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0006367transcription initiation from RNA polymerase II prISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0001087TFIIB-class binding transcription factor activityISSmolecular_function
GO:0045666positive regulation of neuron differentiationISSbiological_process
GO:0001011sequence-specific DNA binding RNA polymerase recruIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region seISSmolecular_function
GO:0001087TFIIB-class binding transcription factor activityIEAmolecular_function
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0070888E-box bindingIEAmolecular_function
GO:0005667transcription factor complexISScellular_component
GO:0001011sequence-specific DNA binding RNA polymerase recruISSmolecular_function
GO:0065004protein-DNA complex assemblyIEAbiological_process
GO:0046982protein heterodimerization activityISSmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0000978RNA polymerase II core promoter proximal region seISSmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0065004protein-DNA complex assemblyISSbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyISSbiological_process