| UniProt/SwissProt ID: | AMHR2_HUMAN |
| Description: | anti-Mullerian hormone receptor, type II [Source:HGNC Symbol;Acc:465] |
| Location: | chr12 q13.13 |
| Node attribute: | PPI(target); receptor; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S189 | EPRPDsGRDWS | PhosphoSitePlus | |
| Dephosphorylation site |
| AMHR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000257863 | D333N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000257863 | E380K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000257863 | R407* | BIOMART | Brain Cancer | 21930507, 21930502 |
| Differential expressed protein |
| AMHR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AMHR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MIS_HUMAN | AMHR2_HUMAN | ligand -> receptor | HPMR |
| GDF7_HUMAN | AMHR2_HUMAN | other | KEGG |
| ITF2_HUMAN | AMHR2_HUMAN | TF -> target gene | TRANSFAC |
| STF1_HUMAN | AMHR2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04350 | TGF-beta signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007548 | sex differentiation | ISS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0007548 | sex differentiation | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005024 | transforming growth factor beta-activated receptor | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005026 | transforming growth factor beta receptor activity, | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | IEA | cellular_component |
| GO:0007179 | transforming growth factor beta receptor signaling | IEA | biological_process |
| GO:0001880 | Mullerian duct regression | NAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0042562 | hormone binding | IPI | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0007165 | signal transduction | IMP | biological_process |
| GO:0004675 | transmembrane receptor protein serine/threonine ki | IEA | molecular_function |
| GO:0004872 | receptor activity | IMP | molecular_function |