| UniProt/SwissProt ID: | ITB7_HUMAN |
| Description: | integrin, beta 7 [Source:HGNC Symbol;Acc:6162] |
| Location: | chr12 q13.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S19 | LSRGEsELDAK | PhosphoSitePlus | |
| T784 | KSAITtTINPR | Integrin_b_cyt | PhosphoSitePlus |
| Y150 | LRAEGyPVDLY | Integrin_beta | PhosphoSitePlus |
| T783 | YKSAItTTINP | PKCb | RegPhos |
| T783 | YKSAItTTINP | PKCd | RegPhos |
| S551 | GRCSCsGQSSG | PhosphoSitePlus | |
| T785 | SAITTtINPRF | Integrin_b_cyt | PhosphoSitePlus |
| S780 | NPLYKsAITTT | Integrin_b_cyt | PhosphoSitePlus |
| Y778 | DSNPLyKSAIT | Tyr-kinases | RegPhos |
| T783 | YKSAItTTINP | PRKCD | HPRD |
| Y753 | LSVEIyDRREY | Integrin_b_cyt | PhosphoSitePlus |
| T783 | YKSAItTTINP | phosphoELM; RegPhos | |
| T783 | YKSAItTTINP | Integrin_b_cyt | PhosphoSitePlus |
| T783 | YKSAItTTINP | PRKCB | HPRD |
| Y758 | YDRREySRFEK | Integrin_b_cyt | PhosphoSitePlus |
| Dephosphorylation site |
| ITB7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000267082 | V185I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000408741 | Y758N | COSMIC | Skin Cancer | 21984974 | ENSP00000267082 | E419K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000267082 | Y753H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000267082 | E259K | COSMIC | Other Cancer | ENSP00000267082 | Y758N | COSMIC | Skin Cancer | 21984974 | ENSP00000408741 | S391F | COSMIC | Melanoma | 21499247 | ENSP00000267082 | D563Y | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000267082 | R649Q | COSMIC | Skin Cancer | 21984974 | ENSP00000408741 | D563Y | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000408741 | Y753H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000267082 | R755G | COSMIC | Skin Cancer | 21984974 | ENSP00000408741 | V185I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000408741 | E259K | COSMIC | Other Cancer | ENSP00000345501 | E419K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000408741 | R649Q | COSMIC | Skin Cancer | 21984974 | ENSP00000408741 | E419K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000267082 | S391F | COSMIC | Melanoma | 21499247 | ENSP00000408741 | R755G | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| ITB7_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ITB7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | ITB7_HUMAN | kinase -> substrate | RegPhos |
| KPCD_HUMAN | ITB7_HUMAN | kinase -> substrate | HPRD |
| KPCB_HUMAN | ITB7_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05414 | Dilated cardiomyopathy |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa04512 | ECM-receptor interaction |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| hsa04510 | Focal adhesion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008305 | integrin complex | IEA | cellular_component |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0050900 | leukocyte migration | IEA | biological_process |
| GO:0007160 | cell-matrix adhesion | IEA | biological_process |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |