Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITB7_HUMAN
Description:integrin, beta 7 [Source:HGNC Symbol;Acc:6162]
Location:chr12 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S19LSRGEsELDAKPhosphoSitePlus
T784KSAITtTINPRIntegrin_b_cytPhosphoSitePlus
Y150LRAEGyPVDLYIntegrin_betaPhosphoSitePlus
T783YKSAItTTINPPKCbRegPhos
T783YKSAItTTINPPKCdRegPhos
S551GRCSCsGQSSGPhosphoSitePlus
T785SAITTtINPRFIntegrin_b_cytPhosphoSitePlus
S780NPLYKsAITTTIntegrin_b_cytPhosphoSitePlus
Y778DSNPLyKSAITTyr-kinasesRegPhos
T783YKSAItTTINPPRKCDHPRD
Y753LSVEIyDRREYIntegrin_b_cytPhosphoSitePlus
T783YKSAItTTINPphosphoELM; RegPhos
T783YKSAItTTINPIntegrin_b_cytPhosphoSitePlus
T783YKSAItTTINPPRKCBHPRD
Y758YDRREySRFEKIntegrin_b_cytPhosphoSitePlus

Dephosphorylation site
ITB7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000267082V185ICOSMICOvarian Cancer21720365
ENSP00000408741Y758NCOSMICSkin Cancer21984974
ENSP00000267082E419KBIOMARTBreast Cancer21930507, 21930502
ENSP00000267082Y753HCOSMICOvarian Cancer21720365
ENSP00000267082E259KCOSMICOther Cancer
ENSP00000267082Y758NCOSMICSkin Cancer21984974
ENSP00000408741S391FCOSMICMelanoma21499247
ENSP00000267082D563YCOSMICHead and Neck Cancer21798897
ENSP00000267082R649QCOSMICSkin Cancer21984974
ENSP00000408741D563YCOSMICHead and Neck Cancer21798897
ENSP00000408741Y753HCOSMICOvarian Cancer21720365
ENSP00000267082R755GCOSMICSkin Cancer21984974
ENSP00000408741V185ICOSMICOvarian Cancer21720365
ENSP00000408741E259KCOSMICOther Cancer
ENSP00000345501E419KBIOMARTBreast Cancer21930507, 21930502
ENSP00000408741R649QCOSMICSkin Cancer21984974
ENSP00000408741E419KBIOMARTBreast Cancer21930507, 21930502
ENSP00000267082S391FCOSMICMelanoma21499247
ENSP00000408741R755GCOSMICSkin Cancer21984974

Differential expressed protein
ITB7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITB7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANITB7_HUMANkinase -> substrateRegPhos
KPCD_HUMANITB7_HUMANkinase -> substrateHPRD
KPCB_HUMANITB7_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton
hsa04672Intestinal immune network for IgA production
hsa04514Cell adhesion molecules (CAMs)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05202Transcriptional misregulation in cancer
hsa04512ECM-receptor interaction
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008305integrin complexIEAcellular_component
GO:0004872receptor activityIEAmolecular_function
GO:0050900leukocyte migrationIEAbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005102receptor bindingIEAmolecular_function
GO:0050776regulation of immune responseTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process


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