Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITB3_HUMAN
Description:integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [Source:HGNC Symbol;Acc:6156]
Location:chr17 q21.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T777LYKEAtSTFTNIntegrin_b_cytPhosphoSitePlus
T779KEATStFTNITAKT1(PKBRegPhos; SysPTM
Y785FTNITyRSRCHPRD; phosphoELM; SysPTM
Y773ANNPLyKEATSIntegrin_b_cytPhosphoSitePlus; SysPTM
T784TFTNItYRGT_Integrin_b_cytPhosphoSitePlus
T779KEATStFTNITPDPK1HPRD; SysPTM
T779KEATStFTNITAKT1HPRD; RegPhos; SysPTM
T227LTDQVtRFNEEIntegrin_betaPhosphoSitePlus
Y773ANNPLyKEATSSRCHPRD; phosphoELM; RegPhos; SysPTM
Y773ANNPLyKEATSphosphoELM; RegPhos; SysPTM
T779KEATStFTNITHPRD; RegPhos; SysPTM
T208CYDMKtTCLPMIntegrin_betaPhosphoSitePlus
Y785FTNITyRGT__Integrin_b_cytPhosphoSitePlus; SysPTM
S439QEKEKsFTIKPIntegrin_betaPhosphoSitePlus
T779KEATStFTNITPDK1HPRD; RegPhos; SysPTM
Y773ANNPLyKEATSSrcRegPhos; SysPTM
Y785FTNITyRSYKphosphoELM; SysPTM
Y785FTNITyRphosphoELM; SysPTM
T779KEATStFTNITPDK-1phosphoELM; SysPTM
Y660NTCNRyCRDEIIntegrin_B_tailPhosphoSitePlus
T779KEATStFTNITIntegrin_b_cytPhosphoSitePlus; SysPTM
Y785FTNITyRGTSykRegPhos; SysPTM
Y785FTNITyRGTSRCRegPhos; SysPTM
Y785FTNITyRGTSrcRegPhos; SysPTM
Y773ANNPLyKEATSSykRegPhos; SysPTM
T777LYKEAtSTFTNPDK-1phosphoELM
T777LYKEAtSTFTNPDK1RegPhos
S778YKEATsTFTNIIntegrin_b_cytPhosphoSitePlus
Y785FTNITyRGTRegPhos; SysPTM
T779KEATStFTNITPDHK1RegPhos; SysPTM
T441KEKSFtIKPVGIntegrin_betaPhosphoSitePlus

Dephosphorylation site
ITB3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262017T629ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000262017G484ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000262017R378CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000262017Y190CBIOMARTBreast Cancer21930507, 21930502
ENSP00000262017A776VCOSMICCentral Nervous System Neoplasms18772890
ENSP00000262017A776VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000262017E232*BIOMARTBreast Cancer21930507, 21930502
ENSP00000262017R378CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000262017V109GBIOMARTBreast Cancer21930507, 21930502
ENSP00000262017T629ITCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000262017G484ECOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262017Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.5915169874
ENSP00000262017Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.415169874

Hyperphosphorylation site
ITB3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANITB3_HUMANkinase -> substrateRegPhos
AKT1_HUMANITB3_HUMANkinase -> substrateHPRD; RegPhos
PDK1_HUMANITB3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANITB3_HUMANkinase -> substrateRegPhos
KSYK_HUMANITB3_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANITB3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa04380Osteoclast differentiation
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04640Hematopoietic cell lineage
hsa04145Phagosome
hsa04512ECM-receptor interaction
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031092platelet alpha granule membraneTAScellular_component
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIMPbiological_process
GO:0016020membraneIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0008305integrin complexIDAcellular_component
GO:0043184vascular endothelial growth factor receptor 2 bindIPImolecular_function
GO:0032369negative regulation of lipid transportIMPbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0001934positive regulation of protein phosphorylationTASbiological_process
GO:0010888negative regulation of lipid storageIMPbiological_process
GO:0045715negative regulation of low-density lipoprotein parIMPbiological_process
GO:0010745negative regulation of macrophage derived foam celIMPbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0045124regulation of bone resorptionTASbiological_process
GO:0030949positive regulation of vascular endothelial growthTASbiological_process
GO:0005161platelet-derived growth factor receptor bindingTASmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0030168platelet activationIMPbiological_process
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0042060wound healingICbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0032147activation of protein kinase activityIMPbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0007229integrin-mediated signaling pathwayTASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0060055angiogenesis involved in wound healingTASbiological_process
GO:0042470melanosomeIDAcellular_component
GO:0071062alphav-beta3 integrin-vitronectin complexTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0035295tube developmentTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0006457protein foldingIDAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0003756protein disulfide isomerase activityIDAmolecular_function
GO:0050748negative regulation of lipoprotein metabolic proceIMPbiological_process
GO:0050839cell adhesion molecule bindingIPImolecular_function
GO:0070527platelet aggregationIMPbiological_process
GO:0004872receptor activityIEAmolecular_function
GO:0014909smooth muscle cell migrationIMPbiological_process