Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITB2_HUMAN
Description:integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [Source:HGNC Symbol;Acc:6155]
Location:chr21 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S756NPLFKsATTTVPRKCDHPRD
T758LFKSAtTTVMNPKC_alphaphosphoELM
T758LFKSAtTTVMNPKCd(PKC deltaRegPhos
S745KEKLKsQWNNDPKC_betaphosphoELM
T759FKSATtTVMNPphosphoELM; RegPhos
T758LFKSAtTTVMNPKCa(PKC alphaRegPhos
S745KEKLKsQWNNDPKC_alphaphosphoELM
S745KEKLKsQWNNDPKCbRegPhos
S745KEKLKsQWNNDPKCdRegPhos
T758LFKSAtTTVMNPRKCBHPRD
S745KEKLKsQWNNDPRKCBHPRD
S745KEKLKsQWNNDPRKCDHPRD
T758LFKSAtTTVMNIntegrin_b_cytPhosphoSitePlus
T758LFKSAtTTVMNPKC_groupphosphoELM; RegPhos
S756NPLFKsATTTVRegPhos
S745KEKLKsQWNNDPKCh(PKC etaRegPhos
S745KEKLKsQWNNDIntegrin_b_cytPhosphoSitePlus
T758LFKSAtTTVMNPKCh(PKC etaRegPhos
T760KSATTtVMNPKPKCaRegPhos
S756NPLFKsATTTVIntegrin_b_cytPhosphoSitePlus
T758LFKSAtTTVMNphosphoELM
S591RRVECsGRGRCEGF_2PhosphoSitePlus
S745KEKLKsQWNNDPKCb(PKC betaRegPhos
S745KEKLKsQWNNDPKC_groupphosphoELM; RegPhos
S756NPLFKsATTTVPKC_groupphosphoELM; RegPhos
S745KEKLKsQWNNDPKCd(PKC deltaRegPhos
T758LFKSAtTTVMNPKC_deltaphosphoELM
T758LFKSAtTTVMNPKCaRegPhos
S756NPLFKsATTTVPKCdRegPhos
T758LFKSAtTTVMNPRKCDHPRD
T758LFKSAtTTVMNPRKCAHPRD
T758LFKSAtTTVMNPRKCHHPRD
T759FKSATtTVMNPIntegrin_b_cytPhosphoSitePlus
S745KEKLKsQWNNDPKC_etaphosphoELM
T758LFKSAtTTVMNPKCdRegPhos
T758LFKSAtTTVMNPKCbRegPhos
T758LFKSAtTTVMNPKChRegPhos
S745KEKLKsQWNNDPKCa(PKC alphaRegPhos
T758LFKSAtTTVMNPKC_etaphosphoELM
S745KEKLKsQWNNDPKC_deltaphosphoELM
T760KSATTtVMNPKPKC_groupphosphoELM; RegPhos
Y735SDLREyRRFEKIntegrin_b_cytPhosphoSitePlus
T760KSATTtVMNPKPRKCAHPRD
T760KSATTtVMNPKIntegrin_b_cytPhosphoSitePlus

Dephosphorylation site
ITB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380950D300HCOSMICOvarian Cancer21720365
ENSP00000303242G228RCOSMICSkin Cancer21984974
ENSP00000380948R456HCOSMICOvarian Cancer20826764
ENSP00000380948G228RCOSMICSkin Cancer21984974
ENSP00000303242I60LCOSMICOvarian Cancer21720365
ENSP00000380948I60LCOSMICOvarian Cancer21720365
ENSP00000347279R456HCOSMICOvarian Cancer20826764
ENSP00000380948D300HCOSMICOvarian Cancer21720365
ENSP00000347279D300HCOSMICOvarian Cancer21720365
ENSP00000380955G228RCOSMICSkin Cancer21984974
ENSP00000380948T708ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000380950G228RCOSMICSkin Cancer21984974
ENSP00000303242R456HCOSMICOvarian Cancer20826764
ENSP00000380955T708ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000380950R456HCOSMICOvarian Cancer20826764
ENSP00000380955R456HCOSMICOvarian Cancer20826764
ENSP00000380950I60LCOSMICOvarian Cancer21720365
ENSP00000347279T708ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000380955I60LCOSMICOvarian Cancer21720365
ENSP00000303242T708ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000380955D300HCOSMICOvarian Cancer21720365
ENSP00000347279G228RCOSMICSkin Cancer21984974
ENSP00000303242D300HCOSMICOvarian Cancer21720365
ENSP00000380950T708ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000347279I60LCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000303242Breast CancerMetastasistissueDown18257521

Hyperphosphorylation site
ITB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANITB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANITB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCB_HUMANITB2_HUMANkinase -> substrateHPRD
KPCL_HUMANITB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANITB2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05150Staphylococcus aureus infection
hsa04650Natural killer cell mediated cytotoxicity
hsa05323Rheumatoid arthritis
hsa05144Malaria
hsa04514Cell adhesion molecules (CAMs)
hsa05133Pertussis
hsa04810Regulation of actin cytoskeleton
hsa05416Viral myocarditis
hsa05134Legionellosis
hsa05166HTLV-I infection
hsa05140Leishmaniasis
hsa05146Amoebiasis
hsa04145Phagosome
hsa05152Tuberculosis
hsa04670Leukocyte transendothelial migration

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0001948glycoprotein bindingIPImolecular_function
GO:0050776regulation of immune responseTASbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0006915apoptotic processNASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0006954inflammatory responseNASbiological_process
GO:0008305integrin complexIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0007267cell-cell signalingNASbiological_process
GO:0008360regulation of cell shapeNASbiological_process
GO:0004872receptor activityIEAmolecular_function
GO:0050730regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0030593neutrophil chemotaxisIDAbiological_process
GO:0050900leukocyte migrationTASbiological_process


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