| UniProt/SwissProt ID: | IRK4_HUMAN |
| Description: | potassium inwardly-rectifying channel, subfamily J, member 4 [Source:HGNC Symbol;Acc:6265] |
| Location: | chr22 q13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T53 | TTCVDtRWRYM | PKCd(PKC delta | RegPhos |
| T53 | TTCVDtRWRYM | PKC_delta | phosphoELM |
| T53 | TTCVDtRWRYM | phosphoELM | |
| T53 | TTCVDtRWRYM | UPF0104; IRK | PhosphoSitePlus |
| Y234 | TQEGEyLPLDQ | IRK | PhosphoSitePlus |
| Dephosphorylation site |
| IRK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306497 | P178S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| IRK4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | IRK4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| IRK4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030659 | cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0005242 | inward rectifier potassium channel activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016323 | basolateral plasma membrane | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006813 | potassium ion transport | TAS | biological_process |
| GO:0008076 | voltage-gated potassium channel complex | TAS | cellular_component |