Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IQGA1_HUMAN
Description:IQ motif containing GTPase activating protein 1 [Source:HGNC Symbol;Acc:6110]
Location:chr15 q26.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y831RDRLQyFRDHIPhosphoSitePlus
S1515YAALNsKATFYRasGAP_CPhosphoSitePlus
Y855KARDDyKTLINIQPhosphoSitePlus
Y1510KLQQTyAALNSHPRD; phosphoELM
S1441DKMKKsKSVKERasGAP_CPhosphoSitePlus
T1451EDSNLtLQEKKHPRD
S1441DKMKKsKSVKEHPRD; phosphoELM; RegPhos
S2ADEVHPRD; phosphoELM
Y140ETTDIyDRKNMCHPhosphoSitePlus
T663PECGEtYHSDLPhosphoSitePlus
S1133KTRLDsSIRNMRasGAPPhosphoSitePlus
S2MSAADeVRegPhos
T1467GLKKLtELGTVRasGAP_CPhosphoSitePlus
S1443MKKSKsVKEDSPKC_epsilonphosphoELM
T1467GLKKLtELGTVHPRD
Y1284FNVDEySDLVTPhosphoSitePlus
S1443MKKSKsVKEDSPKC_groupRegPhos
S1443MKKSKsVKEDSHPRD; phosphoELM
S1147TDKFLsAIVSSHPRD
Y1526GEQVDyYKSYIRasGAP_CPhosphoSitePlus
T1434IRDAKtPDKMKRasGAP_CPhosphoSitePlus
Y172QIQDLyGKVDFPhosphoSitePlus; HPRD; RegPhos
T178GKVDFtEEEINPhosphoSitePlus
S1237LQHAAsNKMFLRasGAPPhosphoSitePlus
S1443MKKSKsVKEDSRasGAP_CPhosphoSitePlus
S2____MsAADEVPhosphoSitePlus
Y694WVKGGyYYYHNWWPhosphoSitePlus
S1443MKKSKsVKEDSPKCe(PKC epsilonRegPhos
Y1478DPKNKyQELINRasGAP_CPhosphoSitePlus
Y385SAAQQyQRRLAPhosphoSitePlus
S1151LSAIVsSVDKIHPRD
Y1158VDKIPyGMRFIRasGAPPhosphoSitePlus
Y736GVTAAyNREQLPhosphoSitePlus; HPRD
Y1510KLQQTyAALNSRasGAP_CPhosphoSitePlus
Y1114ASKLPyDVTPERasGAPPhosphoSitePlus
S1147TDKFLsAIVSSRasGAPPhosphoSitePlus
Y96SLKKIyDREQTCHPhosphoSitePlus
S1152SAIVSsVDKIPHPRD
S730IQSSIsGVTAAHPRD
T1509VKLQQtYAALNRasGAP_CPhosphoSitePlus
T1359EALAKtEVSLTHPRD
Y133LPKIFyPETTDCHPhosphoSitePlus
T557GDAQKtLQALQPhosphoSitePlus
Y1655LNKKFyGK___PhosphoSitePlus
Y695VKGGYyYYHNLWWPhosphoSitePlus
S91SPKVVsLKKIYCHPhosphoSitePlus
S330FRALQsPALGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y77LRNGVyLAKLGCHPhosphoSitePlus
Y654PDVGLyGVIPEPhosphoSitePlus; HPRD; phosphoELM
Y1158VDKIPyGMRFIHPRD
T857RDDYKtLINAEPhosphoSitePlus
T1403FQPGEtLTEILHPRD
S1227RRNLGsIAKMLRasGAPPhosphoSitePlus
S1152SAIVSsVDKIPRasGAPPhosphoSitePlus
Y697GGYYYyHNLETWWPhosphoSitePlus
S1441DKMKKsKSVKEPKC_group RegPhos
Y17VARPHyGSVLDPhosphoSitePlus
S1151LSAIVsSVDKIRasGAPPhosphoSitePlus

Dephosphorylation site
IQGA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000268182R901CCOSMICMelanoma21499247
ENSP00000268182Q954RCOSMICOvarian Cancer21720365
ENSP00000268182P777SCOSMICHead and Neck Cancer21984974
ENSP00000268182Q954RTCGAOvarian Cancer21720365, 18772890
ENSP00000268182W602CCOSMICLung Cancer20668451
ENSP00000268182D141ECOSMICSkin Cancer21984974
ENSP00000268182Q904RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000268182D1311GTCGAOvarian Cancer21720365, 18772890
ENSP00000268182S804FCOSMICCentral Nervous System Neoplasms18772890
ENSP00000268182D807GCOSMICLung Cancer20668451
ENSP00000268182D1311GCOSMICOvarian Cancer21720365
ENSP00000268182F1266LBIOMARTBreast Cancer21930507, 21930502
ENSP00000268182S804FTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000268182S932FBIOMARTBreast Cancer21930507, 21930502
ENSP00000268182Y103CCOSMICPancreatic Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000268182Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4718646787
ENSP00000268182Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000268182Esophageal CancerNormal vs. CancertissueDown0.3119142970
ENSP00000268182Breast CancerNormal vs. Cancercell lineDown0.2216596714
ENSP00000268182Breast CancerNormal vs. Cancercell lineDown0.1716596714
ENSP00000268182Breast CancerNormal vs. CancertissueUp18257521
ENSP00000268182Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.318491314
ENSP00000268182Pancreatic CancerNormal vs. CancertissueUp215526344

Hyperphosphorylation site
IQGA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANIQGA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005096GTPase activator activityTASmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0031252cell leading edgeIEAcellular_component
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0005095GTPase inhibitor activityTASmolecular_function
GO:0036057slit diaphragmISScellular_component
GO:0016328lateral plasma membraneIEAcellular_component
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0005874microtubuleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005884actin filamentTAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005516calmodulin bindingIPImolecular_function
GO:0030496midbodyIDAcellular_component
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0001817regulation of cytokine productionIEAbiological_process
GO:0005099Ras GTPase activator activityIEAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0005509calcium ion bindingTASmolecular_function
GO:0050796regulation of insulin secretionTASbiological_process
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0043547positive regulation of GTPase activityTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0072015glomerular visceral epithelial cell developmentISSbiological_process
GO:0030054cell junctionIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0071277cellular response to calcium ionIDAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0048365Rac GTPase bindingIEAmolecular_function
GO:0035305negative regulation of dephosphorylationIEAbiological_process


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