Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IKZF1_HUMAN
Description:IKAROS family zinc finger 1 (Ikaros) [Source:HGNC Symbol;Acc:13176]
Location:chr7 p12.2
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S289GDKGLsDTPYDPhosphoSitePlus
T291KGLSDtPYDSSPhosphoSitePlus
Y435EEHRAyDLLRAPhosphoSitePlus
Y321NNAINyLGAESPhosphoSitePlus
T333RPLVQtPPGGSPhosphoSitePlus
Y293LSDTPyDSSASPhosphoSitePlus
S384AKLVPsEREASPhosphoSitePlus
S393ASPSNsCQDSTPhosphoSitePlus
Y413RSGLIyLTNHIPhosphoSitePlus
Y348VISPMyQLHKPPhosphoSitePlus
S389SEREAsPSNSCPhosphoSitePlus
T61NVKVEtQSDEEPhosphoSitePlus
S105GSSALsGVGGIPhosphoSitePlus
S391REASPsNSCQDPhosphoSitePlus
T415GLIYLtNHIAPPhosphoSitePlus
S442LLRAAsENSQDPhosphoSitePlus
T398SCQDStDTESNPhosphoSitePlus
S377NLLLLsKAKLVPhosphoSitePlus
S296TPYDSsASYEKPhosphoSitePlus
S361EGTPRsNHSAQPhosphoSitePlus
S295DTPYDsSASYEPhosphoSitePlus
Y299DSSASyEKENEPhosphoSitePlus
S402STDTEsNNEEQPhosphoSitePlus
S269LDRLAsNVAKRPhosphoSitePlus
S298YDSSAsYEKENPhosphoSitePlus
T358PLAEGtPRSNHPhosphoSitePlus
S397NSCQDsTDTESPhosphoSitePlus
S261IGSERsLVLDRPhosphoSitePlus
S445AASENsQDALRPhosphoSitePlus
S63KVETQsDEENGPhosphoSitePlus
S345VVPVIsPMYQLPhosphoSitePlus
S364PRSNHsAQDSAPhosphoSitePlus
S258LCKIGsERSLVPhosphoSitePlus

Dephosphorylation site
IKZF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331614R111*COSMICLymphoma19129520
ENSP00000331614R433SCOSMICLung Cancer
ENSP00000331614S507*COSMICLymphoma18408710
ENSP00000331614G158SCOSMICLymphoma19129520

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000331614Lung CancerNormal vs. CancertissueUp12943690
ENSP00000331614Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
IKZF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IKZF1_HUMANCD8A_HUMANTF -> target geneTRANSFAC
IKZF1_HUMANFAAH1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IKZF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030217T cell differentiationIEAbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005721centromeric heterochromatinIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0016568chromatin modificationIEAbiological_process
GO:0048732gland developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0045660positive regulation of neutrophil differentiationIEAbiological_process
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0060041retina development in camera-type eyeIEAbiological_process
GO:0048535lymph node developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0051138positive regulation of NK T cell differentiationIEAbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0007498mesoderm developmentTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process


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