| UniProt/SwissProt ID: | FAAH1_HUMAN |
| Description: | fatty acid amide hydrolase [Source:HGNC Symbol;Acc:3553] |
| Location: | chr1 p33 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T99 | EAVLFtYVGKA | Amidase | PhosphoSitePlus |
| S440 | NMKSRsAGKLW | Amidase | PhosphoSitePlus |
| Y454 | HEIEVyRKTVI | Amidase | PhosphoSitePlus |
| S434 | LSAFLsNMKSR | Amidase | PhosphoSitePlus |
| Y329 | PLRVGyYETDN | Amidase | PhosphoSitePlus |
| S430 | LLPRLsAFLSN | Amidase | PhosphoSitePlus |
| S88 | VQKLHsRELAP | PhosphoSitePlus | |
| T99 | EAVLFtYVGKA | HPRD | |
| Y329 | PLRVGyYETDN | HPRD; phosphoELM | |
| Y335 | YETDNyTMPSP | HPRD; phosphoELM | |
| Y335 | YETDNyTMPSP | Amidase | PhosphoSitePlus |
| Dephosphorylation site |
| FAAH1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000243167 | K267M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000243167 | S247F | COSMIC | Skin Cancer | 21984974 | ENSP00000243167 | K267M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000243167 | N259S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000243167 | N259S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000243167 | A345D | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000243167 | V543L | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000243167 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| FAAH1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IKZF1_HUMAN | FAAH1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| FAAH1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031090 | organelle membrane | ISS | cellular_component |
| GO:0047372 | acylglycerol lipase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0017064 | fatty acid amide hydrolase activity | IDA | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but | IEA | molecular_function |
| GO:0016884 | carbon-nitrogen ligase activity, with glutamine as | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0012505 | endomembrane system | IEA | cellular_component |
| GO:0009062 | fatty acid catabolic process | IDA | biological_process |