Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IKBB_HUMAN
Description:nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [Source:HGNC Symbol;Acc:7798]
Location:chr19 q13.2
Node attribute:substrate; ubiquitination(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S23DSGLGsLGPDAPhosphoSitePlus; phosphoELM; RegPhos
T239DKPEPtCGRSPAnk_2PhosphoSitePlus
S313SGPCSsSSDSDPhosphoSitePlus; HPRD; RegPhos
S19DEWCDsGLGSLRSK1RegPhos
S23DSGLGsLGPDAIKKaRegPhos
S23DSGLGsLGPDAIKKbRegPhos
S23DSGLGsLGPDARSK1RegPhos
S19DEWCDsGLGSLIKKaRegPhos
S23DSGLGsLGPDACHUKHPRD
T239DKPEPtCGRSPHPRD
S19DEWCDsGLGSLPhosphoSitePlus; phosphoELM; RegPhos
S19DEWCDsGLGSLCHUKHPRD
S315PCSSSsDSDSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S19DEWCDsGLGSLIKKbRegPhos
S23DSGLGsLGPDARSK-1phosphoELM
S19DEWCDsGLGSLRSK-1phosphoELM
S19DEWCDsGLGSLIKBKBHPRD
Y161EAPDTyLAQGPPhosphoSitePlus
S23DSGLGsLGPDAIKBKBHPRD

Dephosphorylation site
IKBB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312988Q69LCOSMICRenal Cancer20054297
ENSP00000312988G58RCOSMICLung Cancer20668451

Differential expressed protein
IKBB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IKBB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IKKA_HUMANIKBB_HUMANkinase -> substrateHPRD; NetPath
ZAGL2_HUMANIKBB_HUMANkinase -> substrateRegPhos
IKKB_HUMANIKBB_HUMANkinase -> substrateHPRD; NetPath
KS6A1_HUMANIKBB_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FBW1A_HUMANIKBB_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway
hsa05145Toxoplasmosis
hsa05169Epstein-Barr virus infection
hsa05168Herpes simplex infection
hsa04621NOD-like receptor signaling pathway
hsa05140Leishmaniasis
hsa04062Chemokine signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04920Adipocytokine signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa05164Influenza A
hsa04722Neurotrophin signaling pathway
hsa05162Measles
hsa05131Shigellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process


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