| UniProt/SwissProt ID: | I17RA_HUMAN |
| Description: | interleukin 17 receptor A [Source:HGNC Symbol;Acc:5985] |
| Location: | chr22 q11.1 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S629 | VREPGsQACLA | PhosphoSitePlus | |
| S708 | CPLLGsPGAGR | PhosphoSitePlus | |
| Y796 | QSDQGyISRSS | PhosphoSitePlus | |
| Dephosphorylation site |
| I17RA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000320936 | V579G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| I17RA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| I17RA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL17_HUMAN | I17RA_HUMAN | ligand -> receptor | HPMR |
| IL17_HUMAN | I17RA_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:1900017 | positive regulation of cytokine production involve | IEA | biological_process |
| GO:0072537 | fibroblast activation | IDA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032747 | positive regulation of interleukin-23 production | IDA | biological_process |
| GO:0030368 | interleukin-17 receptor activity | NAS | molecular_function |