| UniProt/SwissProt ID: | I15RA_HUMAN |
| Description: | interleukin 15 receptor, alpha [Source:HGNC Symbol;Acc:5978] |
| Location: | chr10 p15.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y227 | SLLACyLKSRQ | SYK | HPRD |
| Y191 | SLLACyLKSRQ | SYK | HPRD |
| Dephosphorylation site |
| I15RA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000380423 | *203L | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000369312 | R256G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| I15RA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| I15RA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KSYK_HUMAN | I15RA_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04672 | Intestinal immune network for IgA production |
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0004896 | cytokine receptor activity | TAS | molecular_function |
| GO:0032825 | positive regulation of natural killer cell differe | IEA | biological_process |
| GO:0004871 | signal transducer activity | TAS | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0031965 | nuclear membrane | IEA | cellular_component |