Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HS90B_HUMAN
Description:heat shock protein 90kDa alpha (cytosolic), class B member 1 [Source:HGNC Symbol;Acc:5258]
Location:chr6 p21.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y512GFEVVyMTEPIHSP90PhosphoSitePlus
T104INNLGtIAKSGHATPase_cPhosphoSitePlus
Y430NYKKFyEAFSKHSP90PhosphoSitePlus
S532EFDGKsLVSVTHPRD
Y520EPIDEyCVQQLHSP90PhosphoSitePlus
T309FYKSLtNDWEDHPRD
S226REKEIsDDEAECK2a1(CK2 alphaRegPhos
T579KVEKVtISNRLHSP90PhosphoSitePlus
S124AGADIsMIGQFHATPase_cPhosphoSitePlus
T595CIVTStYGWTAHSP90PhosphoSitePlus
T285EELNKtKPIWTHSP90PhosphoSitePlus
Y301ITQEEyGEFYKHSP90PhosphoSitePlus
Y276KIKEKyIDQEEHSP90PhosphoSitePlus
Y56LDKIRyESLTDHATPase_cPhosphoSitePlus
Y596IVTSTyGWTANHSP90PhosphoSitePlus
T514EVVYMtEPIDEHPRD
S226REKEIsDDEAECK2_alphaphosphoELM
S307GEFYKsLTNDWHSP90PhosphoSitePlus
S45LRELIsNASDAHATPase_cPhosphoSitePlus
S255IEDVGsDEEDDCK2_alphaphosphoELM
S261DEEDDsGKDKKHSP90PhosphoSitePlus
Y305EYGEFyKSLTNHSP90PhosphoSitePlus
S108GTIAKsGTKAFHATPase_cPhosphoSitePlus
S226REKEIsDDEAECK2_groupphosphoELM; RegPhos
S255IEDVGsDEEDDHSP90PhosphoSitePlus
T297NPDDItQEEYGHSP90PhosphoSitePlus
Y485QKSIYyITGESHSP90PhosphoSitePlus
S718GDEDAsRMEEHPRD
S391LPLNIsREMLQHSP90PhosphoSitePlus
S452NRRRLsELLRYHSP90PhosphoSitePlus
S718GDEDAsRMEEVHSP90PhosphoSitePlus
T446IHEDStNRRRLHSP90PhosphoSitePlus
S67PSKLDsGKELKHATPase_cPhosphoSitePlus
S255IEDVGsDEEDDHPRD; phosphoELM; RegPhos
S307GEFYKsLTNDWHPRD
S445GIHEDsTNRRRHPRD
S482KETQKsIYYITHSP90PhosphoSitePlus
S255IEDVGsDEEDDCK2a1(CK2 alphaRegPhos
Y619NSTMGyMMAKKHSP90PhosphoSitePlus
T616LRDNStMGYMMHSP90PhosphoSitePlus
S460LRYHTsQSGDEHSP90PhosphoSitePlus
T89LTLVDtGIGMTHATPase_cPhosphoSitePlus
S365VFIMDsCDELIHSP90PhosphoSitePlus
T309FYKSLtNDWEDHSP90PhosphoSitePlus
T297NPDDItQEEYGHPRD; phosphoELM; RegPhos
Y484TQKSIyYITGEHPRD; phosphoELM; RegPhos
T459LLRYHtSQSGDHSP90PhosphoSitePlus
S452NRRRLsELLRYHPRD
S532EFDGKsLVSVTHSP90PhosphoSitePlus
T537SLVSVtKEGLEHSP90PhosphoSitePlus
T190LKEDQtEYLEEPhosphoSitePlus
S594CCIVTsTYGWTHSP90PhosphoSitePlus
T60RYESLtDPSKLHPRD
S58KIRYEsLTDPSHATPase_cPhosphoSitePlus
S398EMLQQsKILKVHSP90PhosphoSitePlus
S226REKEIsDDEAEHPRD; phosphoELM; RegPhos
S587NRLVSsPCCIVHSP90PhosphoSitePlus
T599STYGWtANMERHSP90PhosphoSitePlus
T94TGIGMtKADLIHATPase_cPhosphoSitePlus
S226REKEIsDDEAEHSP90PhosphoSitePlus
Y484TQKSIyYITGEHSP90PhosphoSitePlus
Y216YPITLyLEKERHSP90PhosphoSitePlus
S615ALRDNsTMGYMHSP90PhosphoSitePlus
S535GKSLVsVTKEGHPRD
Y305EYGEFyKSLTNRegPhos
Y596IVTSTyGWTANHPRD
T637HPIVEtLRQKAHSP90PhosphoSitePlus
S261DEEDDsGKDKKHPRD; phosphoELM; RegPhos
S48LISNAsDALDKHATPase_cPhosphoSitePlus
T214IGYPItLYLEKHSP90PhosphoSitePlus
Y33IINTFySNKEIPhosphoSitePlus
T60RYESLtDPSKLHATPase_cPhosphoSitePlus
T285EELNKtKPIWTHPRD
Y192EDQTEyLEERRHSP90PhosphoSitePlus
S255IEDVGsDEEDDCK2_groupphosphoELM; RegPhos

Dephosphorylation site
HS90B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360709Q18*COSMICLung Cancer20668451
ENSP00000360609M125ICOSMICLung Cancer20668451
ENSP00000325875D572NCOSMICSkin Cancer21984974
ENSP00000360609E471QCOSMICBreast Cancer20668451
ENSP00000360709D572NCOSMICSkin Cancer21984974
ENSP00000360709M125ICOSMICLung Cancer20668451
ENSP00000325875M125ICOSMICLung Cancer20668451
ENSP00000325875Q18*COSMICLung Cancer20668451
ENSP00000360609D572NCOSMICSkin Cancer21984974
ENSP00000360709E471QCOSMICBreast Cancer20668451
ENSP00000360609Q18*COSMICLung Cancer20668451
ENSP00000325875E471QCOSMICBreast Cancer20668451
ENSP00000325875M513VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000360609Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000360609Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000360609Hepatocellular CarcinomaNormal vs. CancertissueUp2.217627933
ENSP00000360609Thyroid CarcinomaNormal vs. CancertissueUp4.217194741
ENSP00000360609follicular thyroid carcinomaNormal vs. CancertissueDown0.6718316623
ENSP00000360609Prostate CancerMetastasistissueUp3.218553995
ENSP00000360609Breast CancerTreatment (metastasis vs. metastasis-suppressed BRMS1)cell lineUp15168732
ENSP00000360609Breast CancerNormal vs. Cancercell lineDown0.2516596714
ENSP00000360609Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.418491314
ENSP00000360609hepatitis B virusNormal vs. Cancercell lineUp1419187611
ENSP00000360609Non-small cell lung carcinomaNormal vs. Cancercell lineUp15359725
ENSP00000360609Colorectal CancerTreatment (none vs transfected with HPV-16 E6 gene)cell lineUp15684709
ENSP00000360609Lung CancerTreatment(none vs transfected with HPV-16 E7 gene)cell lineUp15684709
ENSP00000360609Gastric CancerMetastasiscell lineDown0.6817022644
ENSP00000360609Breast CancerNormal vs. CancertissueUp2.220005186
ENSP00000360609Renal CancerNormal vs. CancertissueUp19164279
ENSP00000360609Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.616807943
ENSP00000360609Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.716807943
ENSP00000360609Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp1.816807943
ENSP00000360609MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.418630942
ENSP00000360609Gastric CancerNormal vs. CancertissueDown0.5315761955

Hyperphosphorylation site
HS90B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANHS90B_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANHS90B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04612Antigen processing and presentation
hsa04141Protein processing in endoplasmic reticulum
hsa04621NOD-like receptor signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05215Prostate cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030235nitric-oxide synthase regulator activityISSmolecular_function
GO:0033160positive regulation of protein import into nucleusIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmNAScellular_component
GO:0007411axon guidanceTASbiological_process
GO:0032564dATP bindingIEAmolecular_function
GO:0060338regulation of type I interferon-mediated signalingIMPbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0060334regulation of interferon-gamma-mediated signaling IMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032435negative regulation of proteasomal ubiquitin-depenIMPbiological_process
GO:0005829cytosolIEAcellular_component
GO:0006457protein foldingIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0071902positive regulation of protein serine/threonine kiIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0031526brush border membraneIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0002135CTP bindingIEAmolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0051082unfolded protein bindingIEAmolecular_function
GO:0006986response to unfolded proteinNASbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0045793positive regulation of cell sizeIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0002134UTP bindingIEAmolecular_function
GO:0009651response to salt stressIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0044325ion channel bindingIEAmolecular_function
GO:0017098sulfonylurea receptor bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0030911TPR domain bindingISSmolecular_function
GO:0006950response to stressIEAbiological_process
GO:0008180signalosomeIDAcellular_component
GO:0001890placenta developmentIEAbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0016234inclusion bodyIEAcellular_component