Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNRPD_HUMAN
Description:heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) [Source:HGNC Symbol;Acc:5036]
Location:chr4 q21.22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S105FIGGLsWDTTKRRM_1PhosphoSitePlus
Y352GHQNSyKPY__PhosphoSitePlus
S190FVGGLsPDTPERRM_1PhosphoSitePlus
S87SSPRHsEAATAPhosphoSitePlus; phosphoELM; RegPhos
T174GLSPDtPEEKIHPRD
S83GHSNSsPRHSEGSK3B(GSK3 betaRegPhos
T193GLSPDtPEEKIRRM_1PhosphoSitePlus
S82EGHSNsSPRHSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S171FVGGLsPDTPEHPRD
T108EVVDCtLKLDPHPRD
T91HSEAAtAQREEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T127EVVDCtLKLDPHPRD; phosphoELM
T127EVVDCtLKLDPRRM_1PhosphoSitePlus
S190FVGGLsPDTPEHPRD; phosphoELM; RegPhos
S80EDEGHsNSSPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S87SSPRHsEAATAPRKACAHPRD
Y332YGYGDySNQQSPhosphoSitePlus
S71AKIDAsKNEEDCBFNTPhosphoSitePlus
Y263MSKEQyQQQQQNIDPhosphoSitePlus
S87SSPRHsEAATAPKA_groupphosphoELM; RegPhos
Y329NNYYGyGDYSNPhosphoSitePlus
S83GHSNSsPRHSEGSK3BHPRD; RegPhos
T193GLSPDtPEEKIHPRD; phosphoELM; RegPhos
S83GHSNSsPRHSEPhosphoSitePlus; phosphoELM; RegPhos
S71AKIDAsKNEEDHPRD
S83GHSNSsPRHSEGSK-3_betaphosphoELM
S87SSPRHsEAATAPKACaRegPhos

Dephosphorylation site
HNRPD_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305860Q269EBIOMARTBreast Cancer21930507, 21930502
ENSP00000313199Q288EBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000313199Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000313199Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.4819422301
ENSP00000313199Pancreatic CancerNormal vs. CancertissueUp2419199705

Hyperphosphorylation site
HNRPD_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANHNRPD_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANHNRPD_HUMANkinase -> substrateRegPhos
KPCA_HUMANHNRPD_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
HNRPD_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0043488regulation of mRNA stabilityIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0006396RNA processingTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0042162telomeric DNA bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006401RNA catabolic processTASbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0008380RNA splicingTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0003723RNA bindingNASmolecular_function


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