Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HNRH3_HUMAN
Description:heterogeneous nuclear ribonucleoprotein H3 (2H9) [Source:HGNC Symbol;Acc:5043]
Location:chr10 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y153GGFDDyGGYNNPhosphoSitePlus; HPRD
T49NGITLtMDYQGRRM_1PhosphoSitePlus
Y156DDYGGyNNYGYPhosphoSitePlus
Y147GYDGGyGGFDDPhosphoSitePlus; HPRD
T314SGGYGtPDGLGPhosphoSitePlus
S201IANFFsPLNPIHPRD
S216IANFFsPLNPIRRM_1PhosphoSitePlus; SysPTM
Y332GSGGYyGQGGMPhosphoSitePlus
S283QGGYGsVGRMGHPRD
S254ELFLNsTPGGGHPRD
Y331GGSGGyYGQGGPhosphoSitePlus
T47VPNGItLTMDYRRM_1PhosphoSitePlus
Y296DNQGGyGSVGRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T17DASDGtVRLRGPhosphoSitePlus
T255LFLNStPGGGSHPRD
Y159GGYNNyGYGNDPhosphoSitePlus; HPRD
S216IANFFsPLNPIHPRD; phosphoELM; SysPTM
Y308GMGNNySGGYGPhosphoSitePlus
Y312NYSGGyGTPDGPhosphoSitePlus
Y100EIKGFyDPPRRPhosphoSitePlus
T207LPFRAtENDIARRM_1PhosphoSitePlus
Y281DNQGGyGSVGRHPRD
Y321DGLGGyGRGGGPhosphoSitePlus
Y181MGGHGyGGAGDPhosphoSitePlus
Y52TLTMDyQGRSTRRM_1PhosphoSitePlus
T270LFLNStPGGGSPhosphoSitePlus; HPRD
S298QGGYGsVGRMGPhosphoSitePlus; HPRD; SysPTM
S28LPFGCsKEEIVRRM_1PhosphoSitePlus
Y161YNNYGyGNDGFPhosphoSitePlus
Y143RGGDGyDGGYGPhosphoSitePlus; HPRD
S269ELFLNsTPGGGHPRD

Dephosphorylation site
HNRH3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265866*347SCOSMICOvarian Cancer21720365
ENSP00000265866G341RTCGAOvarian Cancer21720365, 18772890
ENSP00000265866*347CCOSMICOvarian Cancer21720365
ENSP00000265866G341RCOSMICOvarian Cancer21720365
ENSP00000265866G326RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265866Hepatocellular CarcinomaNormal vs. Cancercell lineUp218646787
ENSP00000265866Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineDown0.7917152098
ENSP00000265866chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730

Hyperphosphorylation site
HNRH3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK24_HUMANHNRH3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
HNRH3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008380RNA splicingTASbiological_process
GO:0003723RNA bindingNASmolecular_function
GO:0006396RNA processingTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0000398mRNA splicing, via spliceosomeNASbiological_process
GO:0005634nucleusIDAcellular_component


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