| UniProt/SwissProt ID: | HNRH3_HUMAN |
| Description: | heterogeneous nuclear ribonucleoprotein H3 (2H9) [Source:HGNC Symbol;Acc:5043] |
| Location: | chr10 q21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y153 | GGFDDyGGYNN | PhosphoSitePlus; HPRD | |
| T49 | NGITLtMDYQG | RRM_1 | PhosphoSitePlus |
| Y156 | DDYGGyNNYGY | PhosphoSitePlus | |
| Y147 | GYDGGyGGFDD | PhosphoSitePlus; HPRD | |
| T314 | SGGYGtPDGLG | PhosphoSitePlus | |
| S201 | IANFFsPLNPI | HPRD | |
| S216 | IANFFsPLNPI | RRM_1 | PhosphoSitePlus; SysPTM |
| Y332 | GSGGYyGQGGM | PhosphoSitePlus | |
| S283 | QGGYGsVGRMG | HPRD | |
| S254 | ELFLNsTPGGG | HPRD | |
| Y331 | GGSGGyYGQGG | PhosphoSitePlus | |
| T47 | VPNGItLTMDY | RRM_1 | PhosphoSitePlus |
| Y296 | DNQGGyGSVGR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T17 | DASDGtVRLRG | PhosphoSitePlus | |
| T255 | LFLNStPGGGS | HPRD | |
| Y159 | GGYNNyGYGND | PhosphoSitePlus; HPRD | |
| S216 | IANFFsPLNPI | HPRD; phosphoELM; SysPTM | |
| Y308 | GMGNNySGGYG | PhosphoSitePlus | |
| Y312 | NYSGGyGTPDG | PhosphoSitePlus | |
| Y100 | EIKGFyDPPRR | PhosphoSitePlus | |
| T207 | LPFRAtENDIA | RRM_1 | PhosphoSitePlus |
| Y281 | DNQGGyGSVGR | HPRD | |
| Y321 | DGLGGyGRGGG | PhosphoSitePlus | |
| Y181 | MGGHGyGGAGD | PhosphoSitePlus | |
| Y52 | TLTMDyQGRST | RRM_1 | PhosphoSitePlus |
| T270 | LFLNStPGGGS | PhosphoSitePlus; HPRD | |
| S298 | QGGYGsVGRMG | PhosphoSitePlus; HPRD; SysPTM | |
| S28 | LPFGCsKEEIV | RRM_1 | PhosphoSitePlus |
| Y161 | YNNYGyGNDGF | PhosphoSitePlus | |
| Y143 | RGGDGyDGGYG | PhosphoSitePlus; HPRD | |
| S269 | ELFLNsTPGGG | HPRD | |
| Dephosphorylation site |
| HNRH3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265866 | *347S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265866 | G341R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265866 | *347C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265866 | G341R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265866 | G326R | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000265866 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2 | 18646787 | ENSP00000265866 | Prostate Cancer | Treatment (none vs. bicalutamide treatment) | cell line | Down | 0.79 | 17152098 | ENSP00000265866 | chronic myeloid leukemia | Treatment (Imatinib-sensitive vs. Imatinib-resistant) | cell line | Down | 20417730 |
| Hyperphosphorylation site |
| HNRH3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK24_HUMAN | HNRH3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| HNRH3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IEA | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | NAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |