| UniProt/SwissProt ID: | HMGN2_HUMAN |
| Description: | high mobility group nucleosomal binding domain 2 [Source:HGNC Symbol;Acc:4986] |
| Location: | chr1 p36.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S29 | RSARLsAKPAP | PKCa | RegPhos |
| S25 | EPQRRsARLSA | PKCa | RegPhos |
| S29 | RSARLsAKPAP | RSK2 | RegPhos |
| S29 | RSARLsAKPAP | PKG_group | RegPhos |
| S25 | EPQRRsARLSA | RPS6KA3 | HPRD |
| S25 | EPQRRsARLSA | PRKACA | HPRD |
| S29 | RSARLsAKPAP | PKACa | RegPhos |
| S29 | RSARLsAKPAP | HMG14_17 | PhosphoSitePlus |
| S25 | EPQRRsARLSA | HMG14_17 | PhosphoSitePlus |
| S25 | EPQRRsARLSA | PRKCA | HPRD |
| S29 | RSARLsAKPAP | PRKACA | HPRD |
| S29 | RSARLsAKPAP | RPS6KA3 | HPRD |
| S29 | RSARLsAKPAP | PRKCA | HPRD |
| S25 | EPQRRsARLSA | RSK2 | RegPhos |
| S29 | RSARLsAKPAP | PKG/cGK_group | phosphoELM |
| S25 | EPQRRsARLSA | PKACa | RegPhos |
| Dephosphorylation site |
| HMGN2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| HMGN2_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000355228 | Breast Cancer | Normal vs. Cancer | tissue | Up | 20560667 | ENSP00000355228 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.39 | 19610612 |
| Hyperphosphorylation site |
| HMGN2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6A3_HUMAN | HMGN2_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | HMGN2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| HMGN2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | cellular_component |
| GO:0005634 | nucleus | NAS | cellular_component |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0031492 | nucleosomal DNA binding | IEA | molecular_function |
| GO:0006325 | chromatin organization | NAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |