Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HMDH_HUMAN
Description:3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:5006]
Location:chr5 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T389SVEEEtGINREPhosphoSitePlus
S420FVVGNsSLLDTPhosphoSitePlus
T431SSVLVtQEPEIPhosphoSitePlus
T884LQGACtKKTA_PhosphoSitePlus
S637QKLHTsIAGRNHMG-CoA_redPhosphoSitePlus
S278WIADPsPQNSTPhosphoSitePlus
S261VKMIMsLGLVLPhosphoSitePlus
T286NSTADtSKVSLPhosphoSitePlus
S872MIHNRsKINLQPRKACAHPRD
S463GAKFLsDAEIIPhosphoSitePlus
S427LLDTSsVLVTQPhosphoSitePlus
S504LSKKLsEPSSLHMG-CoA_redPhosphoSitePlus
Y644AGRNLyIRFQSHMG-CoA_redPhosphoSitePlus

Dephosphorylation site
HMDH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000287936P277ATCGAOvarian Cancer21720365, 18772890
ENSP00000287936P277ACOSMICOvarian Cancer21720365
ENSP00000426745P277ATCGAOvarian Cancer21720365, 18772890
ENSP00000426745P277ACOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000287936Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.4615169874

Hyperphosphorylation site
HMDH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANHMDH_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04976Bile secretion
hsa01100Metabolic pathways
hsa00900Terpenoid backbone biosynthesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0050661NADP bindingIEAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0007568agingIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0045445myoblast differentiationIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0050662coenzyme bindingIEAmolecular_function
GO:0010666positive regulation of cardiac muscle cell apoptotIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0061045negative regulation of wound healingIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0042282hydroxymethylglutaryl-CoA reductase activityIEAmolecular_function
GO:0051262protein tetramerizationIDAbiological_process
GO:0006695cholesterol biosynthetic processIEAbiological_process
GO:0006743ubiquinone metabolic processIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0016616oxidoreductase activity, acting on the CH-OH groupIEAmolecular_function
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activiIEAmolecular_function
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0032874positive regulation of stress-activated MAPK cascaIEAbiological_process
GO:0008299isoprenoid biosynthetic processIEAbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0005778peroxisomal membraneIDAcellular_component
GO:0008158hedgehog receptor activityIEAmolecular_function
GO:0061179negative regulation of insulin secretion involved IEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0015936coenzyme A metabolic processIEAbiological_process
GO:0045908negative regulation of vasodilationIEAbiological_process
GO:0070402NADPH bindingIDAmolecular_function
GO:0007584response to nutrientIEAbiological_process
GO:0048643positive regulation of skeletal muscle tissue deveIEAbiological_process
GO:0010664negative regulation of striated muscle cell apoptoIEAbiological_process
GO:0008542visual learningIEAbiological_process