Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HIRA_HUMAN
Description:HIR histone cell cycle regulation defective homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:4916]
Location:chr22 q11.21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T576ERSKAtPGAPAPhosphoSitePlus; HPRD; phosphoELM
S697FTLQVsSDPSMPhosphoSitePlus
Y953NEGFEyRLREIHiraPhosphoSitePlus
T393EAQLStAVIENPhosphoSitePlus; HPRD
T586ALTSMtPTAVEPhosphoSitePlus; HPRD; phosphoELM
T583GAPALtSMTPTPhosphoSitePlus; HPRD; phosphoELM
T554SPSVLtTPSKIPhosphoSitePlus
S538SVNKDsMNATSHPRD
S650RPRKDsRLMPVPhosphoSitePlus
Y404PEMLKyQRRQQPhosphoSitePlus
S584APALTsMTPTAPhosphoSitePlus; HPRD; phosphoELM
S661SLSVQsPAALTPhosphoSitePlus; HPRD; phosphoELM
S549TPAALsPSVLTPhosphoSitePlus; HPRD
S557VLTTPsKIEPMPhosphoSitePlus; HPRD
S614ESSSDsDEKVPPhosphoSitePlus; HPRD; phosphoELM
S815EESLHsILAGSHiraPhosphoSitePlus
T555PSVLTtPSKIECDK2HPRD; phosphoELM; RegPhos
S687KLPIPsPQRAFCDK2HPRD; RegPhos
T711VENEVtVVGGVPhosphoSitePlus
S551AALSPsVLTTPHPRD
S687KLPIPsPQRAFPhosphoSitePlus; phosphoELM; RegPhos
T544MNATStPAALSPhosphoSitePlus
T588TSMTPtAVERLPhosphoSitePlus
S812VVKEEsLHSILHiraPhosphoSitePlus
T555PSVLTtPSKIEPhosphoSitePlus
Y945LVYARyLVNEGHiraPhosphoSitePlus
S610RDLLEsSSDSDPhosphoSitePlus; HPRD; phosphoELM
S611DLLESsSDSDEPhosphoSitePlus; HPRD; phosphoELM
S612LLESSsDSDEKPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
HIRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000345350E254*BIOMARTBreast Cancer21930507, 21930502
ENSP00000263208M423ICOSMICOvarian Cancer21720365
ENSP00000263208E254*BIOMARTBreast Cancer21930507, 21930502
ENSP00000263208Q922HCOSMICOvarian Cancer21720365

Differential expressed protein
HIRA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HIRA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANHIRA_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANHIRA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
HIRA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0016568chromatin modificationIEAbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0016605PML bodyIEAcellular_component
GO:0000790nuclear chromatinIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0007369gastrulationIEAbiological_process
GO:0042692muscle cell differentiationIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0005634nucleusTAScellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23