Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HDAC2_HUMAN
Description:histone deacetylase 2 [Source:HGNC Symbol;Acc:4853]
Location:chr6 q21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T39HRIRMtHNLLLHist_deacetylPhosphoSitePlus
S394AVHEDsGDEDGCK2a1(CK2 alphaRegPhos; SysPTM
S394AVHEDsGDEDGCK2a1RegPhos; SysPTM
S394AVHEDsGDEDGCK2a2RegPhos; SysPTM
S407PDKRIsIRASDPhosphoSitePlus; phosphoELM; RegPhos
S424EEFSDsEDEGEPhosphoSitePlus; phosphoELM; RegPhos
S422CDEEFsDSEDECK2a1RegPhos
S394AVHEDsGDEDGCK2_alphaphosphoELM; SysPTM
Y222AGKGKyYAVNFHist_deacetylPhosphoSitePlus
S394AVHEDsGDEDGPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S422CDEEFsDSEDECK2_groupphosphoELM; RegPhos
S394AVHEDsGDEDGCK2a1-rsRegPhos; SysPTM
S424EEFSDsEDEGECK2a1-rsRegPhos
S411ISIRAsDKRIAPhosphoSitePlus
Y337NDYFEyFGPDFPhosphoSitePlus
T477GEKTDtKGTKSPhosphoSitePlus
S422CDEEFsDSEDECK2a2RegPhos
S422CDEEFsDSEDECK2a1-rsRegPhos
Y334LPYNDyFEYFGPhosphoSitePlus
Y205HKYGEyFPGTGHist_deacetylPhosphoSitePlus
Y46NLLLNyGLYRKHist_deacetylPhosphoSitePlus
S422CDEEFsDSEDEPhosphoSitePlus; phosphoELM; RegPhos
Y88DNMSEySKQMQHist_deacetylPhosphoSitePlus
S424EEFSDsEDEGECK2a1RegPhos
Y3___MAySQGGGPhosphoSitePlus
S424EEFSDsEDEGECK2a2RegPhos
Y49LNYGLyRKMEIHist_deacetylPhosphoSitePlus
S394AVHEDsGDEDGCK2_groupphosphoELM; RegPhos; SysPTM
Y359QNTPEyMEKIKPhosphoSitePlus
S424EEFSDsEDEGECK2_groupphosphoELM; RegPhos

Dephosphorylation site
HDAC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000430432R409*COSMICMelanoma20016485
ENSP00000430432Q261PCOSMICCentral Nervous System Neoplasms21817013
ENSP00000430432G181VCOSMICCentral Nervous System Neoplasms21817013
ENSP00000430432E109QCOSMICOvarian Cancer20826764
ENSP00000430432K166NCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
HDAC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HDAC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK22_HUMANHDAC2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANHDAC2_HUMANkinase -> substrateRegPhos
CSK21_HUMANHDAC2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa05016Huntington's disease
hsa05203Viral carcinogenesis
hsa05200Pathways in cancer
hsa04110Cell cycle
hsa04330Notch signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05034Alcoholism
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045786negative regulation of cell cycleTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060789hair follicle placode formationIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0032967positive regulation of collagen biosynthetic proceICbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0016358dendrite developmentIEAbiological_process
GO:0045862positive regulation of proteolysisIMPbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0005657replication forkIEAcellular_component
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0048714positive regulation of oligodendrocyte differentiaIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0016575histone deacetylationIMPbiological_process
GO:0017053transcriptional repressor complexIEAcellular_component
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0061029eyelid development in camera-type eyeIEAbiological_process
GO:0016580Sin3 complexIDAcellular_component
GO:0016581NuRD complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0001103RNA polymerase II repressing transcription factor IPImolecular_function
GO:0033558protein deacetylase activityIEAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0021766hippocampus developmentIEAbiological_process
GO:0046970NAD-dependent histone deacetylase activity (H4-K16IEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiIMPbiological_process
GO:0032041NAD-dependent histone deacetylase activity (H3-K14IEAmolecular_function
GO:0097372NAD-dependent histone deacetylase activity (H3-K18IEAmolecular_function
GO:0035098ESC/E(Z) complexIDAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenICbiological_process
GO:0090311regulation of protein deacetylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0033558protein deacetylase activityIMPmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0016575histone deacetylationIEAbiological_process
GO:0045347negative regulation of MHC class II biosynthetic pICbiological_process
GO:0061198fungiform papilla formationIEAbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 IEAmolecular_function
GO:0000792heterochromatinIEAcellular_component
GO:0009913epidermal cell differentiationIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenICbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0006344maintenance of chromatin silencingIMPbiological_process
GO:0006338chromatin remodelingICbiological_process
GO:0003682chromatin bindingISSmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0006476protein deacetylationIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0010870positive regulation of receptor biosynthetic proceIMPbiological_process
GO:0004407histone deacetylase activityIEAmolecular_function